Protein Alignment HNRNPA1 and eIF3g2

DIOPT Version :10

• Sequence 1: NP_112420.1
• Gene: HNRNPA1 / 3178
• HGNCID: 5031
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_650887.1
• Gene: eIF3g2 / 42422
• FlyBaseID: FBgn0038796
• Length: 273
• Species: Drosophila melanogaster
• Alignment Length: 196
• Identity: 41/196 - (20%)
• Similarity: 67/196 - (34%)
• Gaps: 48/196 - (24%)

Human     4 SESPKEPEQLRKLFIGGLSFETTDESLRS-----------HFEQWGTLTDCVVMRDPNTKRSRGF 57
            |::....|::...|||...|:.|.|:...           :.|.|.  .:|     |....|...
  Fly    84 SQTTMASEEIFMQFIGSKDFDQTHETQLDPGKNIAKCRICNGEHWS--VNC-----PYKGTSMDS 141

Human    58 GFVTYATVEEVDAAMNARPHKVDGRVVEP--------------KRAVSREDSQRPGAHLTVKKIF 108
            ..|.........||..:.|.|. |:.|.|              .|...|:||         ..:.
  Fly   142 KTVMETKANAAAAAAISDPSKT-GKYVPPFMKDGGGISGSKNWGRGRDRDDS---------SAVR 196

Human   109 VGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFD-DHDSVDKIVIQKYHTVNG 172
            :..:.|...|..|.:..::.|....:.:..::.||..:|||:|.|. ..|:...|.:     :||
  Fly   197 ISNLSESMTETDLEELVKKIGPHTKMYLAREKNSGLCKGFAYVHFKFRQDAAAAIEV-----LNG 256

Human   173 H 173
            |
  Fly   257 H 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPA1	NP_112420.1	Globular A domain	4..94		23/114 (20%)
		RRM1_hnRNPA1	12..92	CDD:410154	20/104 (19%)
		Globular B domain	95..185		17/80 (21%)
		RRM2_hnRNPA3	105..184	CDD:409996	16/70 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..216
		RNA-binding RGG-box	218..240
		HnRNPA1	312..344	CDD:463312
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..372
		Nuclear targeting sequence (M9)	320..357
eIF3g2	NP_650887.1	eIF3g	28..137	CDD:463545	12/59 (20%)
		RRM_eIF3G_like	195..269	CDD:409842	16/68 (24%)