Protein Alignment HNRNPA1 and hnrnpa1b

DIOPT Version :10

• Sequence 1: NP_112420.1
• Gene: HNRNPA1 / 3178
• HGNCID: 5031
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_956398.3
• Gene: hnrnpa1b / 378453
• ZFINID: ZDB-GENE-030912-14
• Length: 403
• Species: Danio rerio
• Alignment Length: 423
• Identity: 277/423 - (65%)
• Similarity: 307/423 - (72%)
• Gaps: 71/423 - (16%)

Human     1 MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATV 65
            |||...|:|||||||||||||||||||:|||:||||||||||||||:|||||||||||||||::|
Zfish     1 MSKEGQPREPEQLRKLFIGGLSFETTDDSLRAHFEQWGTLTDCVVMKDPNTKRSRGFGFVTYSSV 65

Human    66 EEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGK 130
            :||:|:|:|||||||||:||||||||||||.:|.||.|||||||||||:||||:||||||:|:||
Zfish    66 DEVNASMDARPHKVDGRLVEPKRAVSREDSSKPFAHTTVKKIFVGGIKDDTEENHLRDYFDQFGK 130

Human   131 IEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRG 195
            |||:|||.|..:|.||||||||||||||||:||||||||||||||||||||||||||:.     |
Zfish   131 IEVVEIMVDHKTGNKRGFAFVTFDDHDSVDRIVIQKYHTVNGHNCEVRKALSKQEMANT-----G 190

Human   196 RSGSGNFGGGR-----------------GGGFGGNDN--FGRGGNFSGRGGFGGSRGGGGYGGSG 241
            |.|.|..||.|                 |||.|||.:  |||||..:..||.||  |||||||.|
Zfish   191 RGGGGGGGGDRGNFNRYGNNGGYNNDFGGGGGGGNRDGYFGRGGRGNNFGGGGG--GGGGYGGGG 253

Human   242 DGYN--------GFGNDGGYGGGGPGYSGGSRGY---GSGGQGYGNQGSGY------GGSGSYDS 289
            |.||        |:|..||.|||.||..||:|||   |.||.||||||.||      ||.|.|::
Zfish   254 DCYNNNNGFGGGGYGGGGGNGGGSPGNYGGNRGYGGGGGGGHGYGNQGGGYGGGNSGGGGGGYNN 318

Human   290 YNNG----GGGGF-GGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNF--GGRSSGPYGGGGQY 347
            ||||    |||.| |||.|.|.||||:||||||||:|.||:|||| |||  |||:|||||
Zfish   319 YNNGNGNFGGGNFGGGGGGGNSGGGGNYNDFGNYNSQQSNYGPMK-GNFGGGGRNSGPYG----- 377

Human   348 FAKPRNQGGYGGSSS-----SSSYG---SGRRF 372
                   |||||.||     .|.||   .||||
Zfish   378 -------GGYGGGSSGSGGGGSGYGGGSGGRRF 403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPA1	NP_112420.1	Globular A domain	4..94		75/89 (84%)
		RRM1_hnRNPA1	12..92	CDD:410154	69/79 (87%)
		Globular B domain	95..185		74/89 (83%)
		RRM2_hnRNPA3	105..184	CDD:409996	67/78 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..216		19/52 (37%)
		RNA-binding RGG-box	218..240		13/21 (62%)
		HnRNPA1	312..344	CDD:463312	26/33 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..372		33/64 (52%)
		Nuclear targeting sequence (M9)	320..357		19/38 (50%)
hnrnpa1b	NP_956398.3	None