Protein Alignment HNRNPA1 and CG12288

DIOPT Version :10

• Sequence 1: NP_112420.1
• Gene: HNRNPA1 / 3178
• HGNCID: 5031
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_609822.1
• Gene: CG12288 / 35027
• FlyBaseID: FBgn0032620
• Length: 435
• Species: Drosophila melanogaster
• Alignment Length: 211
• Identity: 52/211 - (24%)
• Similarity: 86/211 - (40%)
• Gaps: 26/211 - (12%)

Human    11 EQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTK-------RSRGFGFVTYATVEEV 68
            |:...:|:|.|...|....|...|:.:| |...:.:|....|       |........|..:|:.
  Fly   152 EEASTVFVGNLPINTKRVQLVKLFQPYG-LVQSIRLRTAGGKQLFKHKQRKVAGSLNAYVVLEKP 215

Human    69 D-----AAMNARPHKVDGRVVEPKRAVSR----EDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDY 124
            :     .|:|....|.:...|.|.....:    :|.| |......:.||||.:|....|..||:.
  Fly   216 EIAQQALALNGSEFKENHLRVTPASMAEKFGQAKDKQ-PSDKDAKRTIFVGSLKYSATEEQLREI 279

Human   125 FEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHT------VNGHNCEVRKALSK 183
            |...|:|:.|..:.|...|.| |.|:|.|...|:|. :.::...|      :|....:|:|..:|
  Fly   280 FSSCGEIDYIRCLQDGDKGCK-GVAYVCFQKPDAVG-LALELNQTLLDDRPINVERYQVKKLGAK 342

Human   184 QEMASASSSQRGRSGS 199
            |...:|::|...::.|
  Fly   343 QVRDAAAASAASKTSS 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPA1	NP_112420.1	Globular A domain	4..94		19/98 (19%)
		RRM1_hnRNPA1	12..92	CDD:410154	18/91 (20%)
		Globular B domain	95..185		28/95 (29%)
		RRM2_hnRNPA3	105..184	CDD:409996	25/84 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..216		5/18 (28%)
		RNA-binding RGG-box	218..240
		HnRNPA1	312..344	CDD:463312
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..372
		Nuclear targeting sequence (M9)	320..357
CG12288	NP_609822.1	RRM1_RBM34	156..237	CDD:409828	16/81 (20%)
		RRM_SF	261..332	CDD:473069	23/72 (32%)