DRSC/TRiP Functional Genomics Resources

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Protein Alignment HNRNPA1 and Hrb27C

DIOPT Version :10

Sequence 1:NP_112420.1 Gene:HNRNPA1 / 3178 HGNCID:5031 Length:372 Species:Homo sapiens
Sequence 2:NP_476869.1 Gene:Hrb27C / 33968 FlyBaseID:FBgn0004838 Length:421 Species:Drosophila melanogaster


Alignment Length:439 Identity:135/439 - (30%)
Similarity:195/439 - (44%) Gaps:114/439 - (25%)


- Green bases have known domain annotations that are detailed below.


Human     9 EPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMN 73
            |.::..|||:||||:|||.|:|..:|.::|.:.|||||::..:.|||||||||:|....|:..:.
  Fly     2 EEDERGKLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQ 66

Human    74 ARPHKVDGRVVEPKRAVSR--EDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEI 136
            ..||.:|||.::||....|  :..::.|.:    |:|:||:..:..|..||.:|.:|||:..:.|
  Fly    67 NGPHTLDGRTIDPKPCNPRTLQKPKKGGGY----KVFLGGLPSNVTETDLRTFFNRYGKVTEVVI 127

Human   137 MTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGN 201
            |.|:...|.|||.|::|::..||:.:..::|..:||...|::||             ..|.|||.
  Fly   128 MYDQEKKKSRGFGFLSFEEESSVEHVTNERYINLNGKQVEIKKA-------------EPRDGSGG 179

Human   202 FGGGR---GGGFG--GND-----------NFGRGGNFSGRGGFGGSRGGG------GYGGSGDGY 244
            .....   ||.:|  ||:           |..:|.|        |..||.      |......||
  Fly   180 QNSNNSTVGGAYGKLGNECSHWGPHHAPINMMQGQN--------GQMGGPPLNMPIGAPNMMPGY 236

Human   245 NGFGNDG-----GYGGGGPGYSGGSRGYGS--GGQGYGNQGSGYGGS------GSYDSYNNGGGG 296
            .|:|...     |||..||   |..:|:|:  |.||...|.|.|.|.      |.||.||:...|
  Fly   237 QGWGTSPQQQQYGYGNSGP---GSYQGWGAPPGPQGPPPQWSNYAGPQQTQGYGGYDMYNSTSTG 298

Human   297 GFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGG---------------NFGGRSSGPYGG--- 343
            ...|.|     ||||:|.:....|.:...|....|               ..|..::||.||   
  Fly   299 APSGPS-----GGGSWNSWNMPPNSAGPTGAPGAGAGTATDMYSRAQAWATGGPSTTGPVGGMPR 358

Human   344 ----------GGQYFAKPRNQGGYGG-----------SSSSSSYGSGRR 371
                      |.:|     :.||||.           ...:|:||:|.|
  Fly   359 TGPGNSASKSGSEY-----DYGGYGSGYDYDYSNYVKQEGASNYGAGPR 402

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HNRNPA1NP_112420.1 Globular A domain 4..94 39/86 (45%)
RRM1_hnRNPA1 12..92 CDD:410154 37/79 (47%)
Globular B domain 95..185 29/89 (33%)
RRM2_hnRNPA3 105..184 CDD:409996 28/78 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..216 9/49 (18%)
RNA-binding RGG-box 218..240 6/27 (22%)
HnRNPA1 312..344 CDD:463312 9/59 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..372 19/94 (20%)
Nuclear targeting sequence (M9) 320..357 11/64 (17%)
Hrb27CNP_476869.1 RRM1_hnRNPA_hnRNPD_like 9..80 CDD:409763 34/70 (49%)
RRM2_DAZAP1 94..173 CDD:409765 29/95 (31%)

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