Protein Alignment org-1 and TBX18

DIOPT Version :10

• Sequence 1: NP_511085.2
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_001073977.1
• Gene: TBX18 / 9096
• HGNCID: 11595
• Length: 607
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 191/646 - (29%)
• Similarity: 273/646 - (42%)
• Gaps: 151/646 - (23%)

  Fly    93 SNSSTSSISNPSCP------DQSSSSSSSSVSLPTDYAGVHSEASMAPTAGGTAVTTTSAGGV-- 149
            :..:..::.:..|.      ::.||......:||.. ||    |:..|...|..:...:|||.
Human    43 AEEAAGAVDDGGCSRGGGAGEKGSSEGDEGAALPPP-AG----ATSGPARSGADLERGAAGGCED 102

  Fly   150 -----SASTASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSLAQAIVVLETKALWDQF 209
                 ::..||.....:.....:.|..||..|:          |..|.     |.|:...||.:|
Human   103 GFQQGASPLASPGGSPKGSPARSLARPGTPLPS----------PQAPR-----VDLQGAELWKRF 152

  Fly   210 HAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKADPI 274
            |..||||||||.||||||..:|:|.|||||..|...||.||:|:|||||.:|:|.|:|||.||..
Human   153 HEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSP 217

  Fly   275 SPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFHLV-------YL 332
            .|||:::||||||.|..||:|::||||||||||:||:.|||||:|||:||||.|::       ..
Human   218 VPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLS 282

  Fly   333 PPKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDGTNDVTTGG-- 395
            |.|.....|.     .:.|.||||.||.|||||||::|:|||..|||||||||.|.|.:....
Human   283 PIKPVPSGEG-----VKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRMGLEALV 342

  Fly   396 ------GSSMSSMSHESQARMKQQQQQQQQQQQQLQQQQQQQQQLKERTAATSN----------F 444
                  ..|:.:::.|....:.:|.........|                .|.|          .
Human   343 ESYAFWRPSLRTLTFEDIPGIPKQGNASSSTLLQ----------------GTGNGVPATHPHLLS 391

  Fly   445 GLSCSELAIEQQQQQQQQQGVLQLPATPSSSSTSGNSPDLLGYQMEQQLQQQHQQQQQQQHQSQQ 509
            |.|||..|........|...:  .||..|:.:.||.:
Human   392 GSSCSSPAFHLGPNTSQLCSL--APADYSACARSGLT---------------------------- 426

  Fly   510 QHLHQQHQANQQQSLLQQSQNHTQYGSYHHAYQAQVQSHPLTPHSSSSASPPATAA-PGASAATA 573
                    .|:..:.|.::.|.                  ||..:..:.:||.|.: .|.|::|:
Human   427 --------LNRYSTSLAETYNR------------------LTNQAGETFAPPRTPSYVGVSSSTS 465

  Fly   574 AVAGGAGAAGAGGATSATQVMSAANIYSSIGQPYAQEQSNFGAIYHHNAAAAAAAHYHHGHAHGH 638
            .   .....|..|.|.:....|.:...|.: .|..|      .|....::.|.|.:..|..::..
Human   466 V---NMSMGGTDGDTFSCPQTSLSMQISGM-SPQLQ------YIMPSPSSNAFATNQTHQGSYNT 520

  Fly   639 AHSHAHAHAHGPYASAYDKLKVSRHAAAAAYG--MGATYPSFYGSAAHHQMMRPNSYIDLV 697
            ...|:....:|...|...||..|.....::.|  :|:: ||  |:....||:.|...:.|:
Human   521 FRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSS-PS--GTMTDRQMLPPVEGVHLL 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_511085.2	T-box_TBX1_10-like	195..385	CDD:410313	112/196 (57%)
TBX18	NP_001073977.1	Engrailed homology 1 repressor. /evidence=ECO:0000305	18..28
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..141		21/117 (18%)
		PHA03307	<32..>139	CDD:223039	20/110 (18%)
		Nuclear localization signal. /evidence=ECO:0000305	36..40
		T-box_TBX15_18_22-like	137..330	CDD:410317	113/202 (56%)