Protein Alignment org-1 and EOMES

DIOPT Version :10

• Sequence 1: NP_511085.2
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_001265111.1
• Gene: EOMES / 8320
• HGNCID: 3372
• Length: 705
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 156/508 - (30%)
• Similarity: 210/508 - (41%)
• Gaps: 122/508 - (24%)

  Fly    71 EQIDAKLADIETHSTGSTGTAN-SNSSTSS----ISNPS---------C---PDQSSSSSSSSVS 118
            |::.:..|.....:..:..||. |..|.||    :.:|.         |   |.|:::.:.....
Human   112 EELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPHGPV 176

  Fly   119 LPTDYAGVHSEASMAPTAG--------GTAVTTTSAGGVSASTASKKFKGQHKKDNNSAENGTVK 175
            .|......:...||.|..|        |.|.....||..|.:..|              ..|...
Human   177 YPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFGPGAGAGSGAGGS--------------SGGGGG 227

  Fly   176 PNSHNISKGESEPV---HPSLA------------------QAIVVLETKALWDQFHAQGTEMIIT 219
            |.::..|:|  .|:   :|..|                  :|.|.|..:.||.:||...||||||
Human   228 PGTYQYSQG--APLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIIT 290

  Fly   220 KTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKAD-PISPPRIHVHP 283
            |.||||||.....|.||:|.|.|...::.|..|...:|  |....||..|||| .:...:::|||
Human   291 KQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWR--FQGGKWVTCGKADNNMQGNKMYVHP 353

  Fly   284 DSPAVGSNWMKQIVSFDKLKLTNNQLDENGH---IILNSMHRYQPRFHLVYLPPKNASLDENEHS 345
            :||..||:||:|.:||.|||||||:...|.:   |:|.|:|:||||.|:|.:...... |.|| .
Human   354 ESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVE-DLNE-P 416

  Fly   346 SHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDD-------GTND------------- 390
            |..:||.|.||.|.|||||||..:|||||..|||||||||:       ..||
Human   417 SKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASENDRLTPSPTDSPRSH 481

  Fly   391 -VTTGGGSSMSSMSHE------SQARMKQQQQQQQQQQQQLQQQQQQQQQLKERTAATSNFGLSC 448
             :..||...:.|...|      .|||....::...|....|..||.:
Human   482 QIVPGGRYGVQSFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSE------------------ 528

  Fly   449 SELAIEQQQ---QQQQQQGVLQLPATPSSSSTSGNSPDLLGYQMEQ-QLQQQH 497
             |:|...|:   ...||.|..:|..  ||..:...|..||.|.::. .||..|
Human   529 -EVANPPQRWLVTPVQQPGTNKLDI--SSYESEYTSSTLLPYGIKSLPLQTSH 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_511085.2	T-box_TBX1_10-like	195..385	CDD:410313	95/193 (49%)
EOMES	NP_001265111.1	T-box_TBR2	266..456	CDD:410331	95/193 (49%)
		T-box_assoc	482..703	CDD:465042	27/118 (23%)