Protein Alignment org-1 and tbr1

DIOPT Version :10

• Sequence 1: NP_511085.2
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_001072587.1
• Gene: tbr1 / 780042
• XenbaseID: XB-GENE-942241
• Length: 677
• Species: Xenopus tropicalis
• Alignment Length: 622
• Identity: 174/622 - (27%)
• Similarity: 238/622 - (38%)
• Gaps: 137/622 - (22%)

  Fly    48 SPMK---------QIEACIQTAGKD------RSSYKPLEQIDAKLADIETHSTGSTGTANSNSST 97
            ||:|         |.||...:..||      ||...|:  :|. :::|.....||..
 Frog    50 SPLKKATVRGMTNQSEADSFSGAKDAPGDGQRSKLSPV--LDG-VSEIRHSFDGSAA-------- 103

  Fly    98 SSISNPSCPDQ----SSSSSSSSVSLPT----DYAGVHSEASMAPTAGGTAVTTTSAGGVSASTA 154
                     |:    .||.|.|:.|.||    .|...|..|..|.:.|       |.|
 Frog   104 ---------DRYLLPQSSQSQSAASAPTTTMFPYPSQHGAAHPAFSLG-------SPG------- 145

  Fly   155 SKKFKGQHKKDNNSAEN---GTVKPNSHNISKG-----------ESEPVH------PSL--AQAI 197
              ::...|....|.|.|   |...|..:. |.|           ::.|.:      |.|  .:|.
 Frog   146 --RYMAHHPVIANGAYNSLLGNSAPQGYP-SAGYPYSQQYGHSYQAAPFYQFSATQPGLVPGKAQ 207

  Fly   198 VVLETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHN 262
            |.|..:.||.:||...|||||||.||||||.....|.||||.|.|...:|.:..|...:|  |..
 Frog   208 VYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWR--FQG 270

  Fly   263 SCWVVAGKADP-ISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQ--LDENGH-IILNSMHRY 323
            ..||..||||. :...|:::|||||..|::||:|.:||.|:|||||:  .:.||. ::|.|:|:|
 Frog   271 GKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKMKLTNNKGASNNNGQMVVLQSLHKY 335

  Fly   324 QPRFHLVYLPPKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDGT 388
            |||.|:|.:  .....::.......:||.||||.|.|||||||..:|||||..|||||||||: .
 Frog   336 QPRLHVVEV--NEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDN-Y 397

  Fly   389 NDVTTGGGSSMSSMSHESQARMKQQQQQQQQQQQQLQQQQQQQQQLKERTAATSNFGLSCSELAI 453
            :.:.||......:.|.....|.:.....:........|.|......|.|
 Frog   398 DTIYTGCDLDRLTPSPNDSPRSQIVPGARYSMASTFLQDQFVSNYAKSR---------------- 446

  Fly   454 EQQQQQQQQQGVLQLPATPSSSSTSGNSPDLLGYQMEQQLQQQHQQQQQQQHQSQQQHLHQQHQA 518
                        ...|.......|..:.|...|....||.:.......|:...:...:......|
 Frog   447 ------------FHPPGAVPGPGTDRSVPHTNGLLSPQQGEDPGAPSPQRWFVTPANNRLDFTSA 499

  Fly   519 NQQQSLLQQSQNHTQYGSYHHAYQAQVQSHPL--------------TPHSSSSASPPATAAPGAS 569
            :...:....:.|.....||   ..|.|::.||              .|....:.|||.......|
 Frog   500 SAYDAATDFAGNAATLLSY---AAAGVKALPLPGGGCTARPLGYYSDPTGWGARSPPQYCTKSGS 561

  Fly   570 AATAAVAGGAGAAGAGGATSATQVMS-AANIYSSIGQ 605
            .......||..||.....|.:.:|.| ||...|.:|:
 Frog   562 VLPCWATGGRMAATNPYLTGSEEVESLAATDRSPLGE 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_511085.2	T-box_TBX1_10-like	195..385	CDD:410313	92/193 (48%)
tbr1	NP_001072587.1	T-box_TBR1	205..395	CDD:410330	92/193 (48%)
		T-box_assoc	420..675	CDD:465042	35/210 (17%)