Protein Alignment org-1 and TBX5

DIOPT Version :9

• Sequence 1: NP_001285019.1
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: XP_016875401.1
• Gene: TBX5 / 6910
• HGNCID: 11604
• Length: 534
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 171/522 - (32%)
• Similarity: 241/522 - (46%)
• Gaps: 116/522 - (22%)

  Fly   182 SKGESEPVHPSLAQAI----VVLETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATY 242
            ||..|.|......|.:    |.|..:.||.:||..||||||||.||||||:::|::.||:|...|
Human    52 SKSPSSPQAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKY 116

  Fly   243 ICMMDFVPMDDKRYRYAFHNSCWVVAGKADPISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNN 307
            |.:||.||.||.||::|  ::.|.|.|||:|..|.|::|||||||.|::||:|:|||.|||||||
Human   117 ILLMDIVPADDHRYKFA--DNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNN 179

  Fly   308 QLDENGHIILNSMHRYQPRFHLVYLPPKNASLDEN----EHSSHFRTFIFPETSFTAVTAYQNQR 368
            .||..|||||||||:||||.|:|       ..|||    ..::.|.|.:||||:|.|||:|||.:
Human   180 HLDPFGHIILNSMHKYQPRLHIV-------KADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHK 237

  Fly   369 VTQLKISSNPFAKGFRDDGTNDVTTGGGSSMSSMSHESQARMKQQQQQQQQQQQQLQQQQQQQQQ 433
            :|||||.:||||||||  |::|:.....|.|.|..:....|        ...:|::.........
Human   238 ITQLKIENNPFAKGFR--GSDDMELHRMSRMQSKEYPVVPR--------STVRQKVASNHSPFSS 292

  Fly   434 LKERTAATSNFGLSCSELAIEQQQQQQQQQGVLQLPATPSSSSTSGNSPDLLGYQMEQQLQQQHQ 498
            .....:.:||.|           .|.|.:.||            ||.|.|||.......|.|:|.
Human   293 ESRALSTSSNLG-----------SQYQCENGV------------SGPSQDLLPPPNPYPLPQEHS 334

  Fly   499 Q-----QQQQQHQSQQQHLHQ----QHQANQQQSLLQQSQNHTQ-YGSYHHAYQAQVQSHPLTPH 553
            |     :::::..|...|.::    :...:::.|..:.|....| .|:.:....||.|:     .
Human   335 QIYHCTKRKEEECSTTDHPYKKPYMETSPSEEDSFYRSSYPQQQGLGASYRTESAQRQA-----C 394

  Fly   554 SSSSASPPA--------------TAAPGASAAT----------------AAVAGG------AGAA 582
            ..:|::||:              .:.|..|:.|                |....|      ||.|
Human   395 MYASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMA 459

  Fly   583 GAGG----------ATSATQ--VMSAANIYSSIGQPYAQEQSNFGAIYHHNAAAAAAAHYHHGHA 635
            ..|.          .||...  |:......:.:..|...:...|  :|.|......:.|.:|. .
Human   460 NHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPGTLQPPEF--LYSHGVPRTLSPHQYHS-V 521

  Fly   636 HG 637
            ||
Human   522 HG 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	112/201 (56%)
TBX5	XP_016875401.1	TBOX	69..257	CDD:238106	111/198 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I3415
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.960