DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment org-1 and TBX2

DIOPT Version :9

Sequence 1:	NP_001285019.1	Gene:	org-1 / 31778	FlyBaseID:	FBgn0021767	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_005985.3	Gene:	TBX2 / 6909	HGNCID:	11597	Length:	712	Species:	Homo sapiens

Alignment Length:	651	Identity:	204/651 - (31%)
Similarity:	277/651 - (42%)	Gaps:	192/651 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 PTAGGTAVTTTSAGGVSASTASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSLAQAIV 198
            |...|.|....:|...:.:.......|.|            .|.:|..|....||.........|
Human    55 PGLAGAAAAAAAAAAAAEAGLHVSALGPH------------PPAAHLRSLKSLEPEDEVEDDPKV 107

  Fly   199 VLETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNS 263
            .||.|.||||||..||||:|||:||||||.|:||:.|||..|.||.:||.|..||.||:  ||||
Human   108 TLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYK--FHNS 170

  Fly   264 CWVVAGKADPISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFH 328
            .|:|||||||..|.|:::||||||.|..||.:.|:|.|||||||..|::|..||||||:||||||
Human   171 RWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFH 235

  Fly   329 LV------YLPPKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDG 387
            :|      .||           .|.|||::||||.|.|||||||.::|||||.:|||||||||
Human   236 IVRANDILKLP-----------YSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRD-- 287

  Fly   388 TNDVTTGGGSSMSSMSHESQARMKQQQQQQQQQQQQLQQQQQQQQQLK-ERTAATSNF------- 444
                 ||.|                  ::::::|..|...:..::..| ||..|.|:.
Human   288 -----TGNG------------------RREKRKQLTLPSLRLYEEHCKPERDGAESDASSCDPPP 329

  Fly   445 --------GLSCSELAI----------------EQQQQQQQQQG--VLQLPATPSSSSTSGNSPD 483
                    |.:.|.|.:                |.::..:::.|  :.:.||..|:|.|....|:
Human   330 AREPPTSPGAAPSPLRLHRARAEEKSCAADSDPEPERLSEERAGAPLGRSPAPDSASPTRLTEPE 394

  Fly   484 ------------------------LLGYQMEQQLQQQHQQQQQQQHQSQQQHLHQQHQANQQQSL 524
                                    |...:.|:...::..:.:::..:.::|.|         ..|
Human   395 RARERRSPERGKEPAESGGDGPFGLRSLEKERAEARRKDEGRKEAAEGKEQGL---------APL 450

  Fly   525 LQQSQNHTQYGSYH--------HAYQAQV-----QSHPLTPHSSS-SASPPATAAPGASAATAAV 575
            :.|:.:.:..|:.|        |.:..|.     ...||..|... :..|.|.:|.|.....|:|
Human   451 VVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAMGMGHLLASV 515

  Fly   576 AGGAGAAG----------AGGATSATQVMSAA---------NIYSSIGQPYAQEQSNFGAI---- 617
            |||....|          |||...|....|.|         ::.:|.|.|    ...||.:
Human   516 AGGGNGGGGGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIP----MPTFGGLFPYP 576

  Fly   618 YHHNAAAAAAAHYHHGHAHGHAHSHAHAHAHGPYASAYDKLKVSRHAAAAAYGMGATYPS-FYGS 681
            |.:.|||||||                           ..|..:..|||||...|:...| |.||
Human   577 YTYMAAAAAAA---------------------------SALPATSAAAAAAAAAGSLSRSPFLGS 614

  Fly   682 A 682
            |
Human   615 A 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	118/199 (59%)
TBX2	NP_005985.3	T-box_TBX2_3-like	103..287	CDD:410314	116/196 (59%)
		PHA03307	300..>467	CDD:223039	25/175 (14%)
		TBX	305..383	CDD:403708	12/77 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..450		19/145 (13%)
		Repression domain 1 (RD1)	518..601		26/113 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840