Protein Alignment org-1 and TBX1

DIOPT Version :9

• Sequence 1: NP_001285019.1
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: XP_016884414.1
• Gene: TBX1 / 6899
• HGNCID: 11592
• Length: 545
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 217/595 - (36%)
• Similarity: 259/595 - (43%)
• Gaps: 200/595 - (33%)

  Fly   133 APTAGGTAVTTTSAGGVSASTASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSLAQAI 197
            ||.||..........|..||.|             :|....||.|:             .:|...
Human   123 APAAGAATSAAAEPEGPGASCA-------------AAAKAPVKKNA-------------KVAGVS 161

  Fly   198 VVLETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHN 262
            |.||.|||||:|:..|||||:||.||||||||||::.|:||.|.|:.:|||||:||||||||||:
Human   162 VQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHS 226

  Fly   263 SCWVVAGKADPISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRF 327
            |.|:|||||||.:|.|:|.||||||.|:.||||||||||||||||.||:||||||||||||||||
Human   227 SSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRF 291

  Fly   328 HLVYLPPKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRD----DGT 388
            |:||:.|:..|  |.....:|:||:|.||.|||||||||.|:|||||:||||||||||    |..
Human   292 HVVYVDPRKDS--EKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWP 354

  Fly   389 NDVTTGGGSSMSSMSHESQARMKQQQQQQQQQQQQLQQQQQQQQQLKERTAATSNFGLSCSELAI 453
            .:...|....||:.:..........|....::.                              |.
Human   355 RNHRPGALPLMSAFARSRNPVASPTQPSGTEKD------------------------------AA 389

  Fly   454 EQQQQQQQQQG---VLQLPATPSSSSTSGNSPDLLGYQMEQQLQQQHQQQQQQQHQSQQQHLHQQ 515
            |.:::.|:..|   ||..||.|         |.||
Human   390 EARREFQRDAGGPAVLGDPAHP---------PQLL------------------------------ 415

  Fly   516 HQANQQQSLLQQSQNHTQYGSYHHAYQAQVQSHPLTPHSSSSASPPATAAPGASAATAAVAGGAG 580
                                       |:|.|..|               ||        |||||
Human   416 ---------------------------ARVLSPSL---------------PG--------AGGAG 430

  Fly   581 A----AGAGGATSATQVMSAANIYSSIGQPYAQEQSNFGAIYHHNAAAAAAAHYHH--------- 632
            .    .||.|...     |..|....:..|.|.|     .::||.....|||:.|:
Human   431 GLVPLPGAPGGRP-----SPPNPELRLEAPGASE-----PLHHHPYKYPAAAYDHYLGAKSRPAP 485

  Fly   633 -------GHA-HGHAHSHAHAHAHGPYASAYDKLKVSRHAAAAAYGMGATYPSFYGSAAHHQMMR 689
                   ||. |.|||.|.|.|...|.|           |||||....|...:.|.||.   ...
Human   486 YPLPGLRGHGYHPHAHPHHHHHPVSPAA-----------AAAAAAAAAAAAANMYSSAG---AAP 536

  Fly   690 PNSYIDLVPR 699
            |.|| |..||
Human   537 PGSY-DYCPR 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	137/197 (70%)
TBX1	XP_016884414.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I1516
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003320
OrthoInspector	1	1.000	-	-		otm42306
orthoMCL	1	0.900	-	-		OOG6_107409
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	1	1.000	-	-		X3735
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.800