DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment org-1 and Tbr1

DIOPT Version :9

Sequence 1:	NP_001285019.1	Gene:	org-1 / 31778	FlyBaseID:	FBgn0021767	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001177999.2	Gene:	Tbr1 / 680427	RGDID:	1591773	Length:	681	Species:	Rattus norvegicus

Alignment Length:	443	Identity:	137/443 - (30%)
Similarity:	195/443 - (44%)	Gaps:	108/443 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTHLMGPTECAGAMMTTTSMQFLDTSLTDYNCYGNDYWTSPYMTGGLSPMKQIEACIQTAGK-DR 64
            :.|.:.|:       ...|.:||:.|        :.|   |: :||...:......|.|... :|
  Rat     3 LEHCLSPS-------IMLSKKFLNVS--------SSY---PH-SGGSELVLHDHPIISTTDNLER 48

  Fly    65 SSYKPLEQIDAKLADIETHSTGSTGTANSNSSTSSISNP------------------------SC 105
            ||  ||::|          :.|.|..:::::...|..:|                        |.
  Rat    49 SS--PLKKI----------TRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSA 101

  Fly   106 PDQ----SSSSSSSSVSLPT---DYAGVHSEASMAPTAGGTAVTTTSAGGVSASTASKKFKGQHK 163
            .|:    .||...|:.:.|:   .|.|.|..|..|.:.|                :..::...|.
  Rat   102 ADRYLLSQSSQPQSAATAPSAMFPYPGQHGPAHPAFSIG----------------SPSRYMAHHP 150

  Fly   164 KDNNSAENGTVKPNS----------------HNISKG---ESEPVHPSL--AQAIVVLETKALWD 207
            ...|.|.|..:..:|                |:....   :.....|.|  .:|.|.|..:.||.
  Rat   151 VITNGAYNSLLSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWL 215

  Fly   208 QFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKAD 272
            :||...|||||||.||||||.....|.||||.|.|...:|.:..|...:|  |....||..||||
  Rat   216 KFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWR--FQGGKWVPCGKAD 278

  Fly   273 P-ISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQ--LDENGH-IILNSMHRYQPRFHLVYLP 333
            . :...|:::|||||..|::||:|.:||.|||||||:  .:.||. ::|.|:|:||||.|:|.:
  Rat   279 TNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEV- 342

  Fly   334 PKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDD 386
             .....::.......:||.||||.|.|||||||..:|||||..|||||||||:
  Rat   343 -NEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDN 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	95/196 (48%)
Tbr1	NP_001177999.2	T-box_TBR1	203..393	CDD:410330	93/193 (48%)
Tbr1	NP_001177999.2	T-box_assoc	418..679	CDD:406561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010