DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment org-1 and tbx1

DIOPT Version :9

Sequence 1:	NP_001285019.1	Gene:	org-1 / 31778	FlyBaseID:	FBgn0021767	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001030290.1	Gene:	tbx1 / 619587	XenbaseID:	XB-GENE-478084	Length:	463	Species:	Xenopus tropicalis

Alignment Length:	571	Identity:	211/571 - (36%)
Similarity:	268/571 - (46%)	Gaps:	143/571 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 FLDTSLTDYNCYGNDYWTSPYMTGGLSPMKQIEACIQTAGKDRSSYKPLEQIDAKLADIETHSTG 86
            |...||:..|..|. |..||      ||           |...|.::|             |...
Frog    22 FTANSLSSLNASGG-YHLSP------SP-----------GDPYSQHEP-------------HYEP 55

  Fly    87 STGTANSNSSTSSISNPSCPDQSSSSSSSSVSLPTDYAGVHSEASMAPTAGGTAVTTTSAGGVSA 151
            .:.:.:|.|     ...:||:..|.:||||.            ||..|.:|.|           .
Frog    56 CSASQHSYS-----FGHACPEPESGASSSSC------------ASSTPGSGST-----------G 92

  Fly   152 STASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSLAQAIVVLETKALWDQFHAQGTEM 216
            |:.|.|              ..||.|             |.:|...|.||.|||||:|:..||||
Frog    93 SSGSSK--------------APVKKN-------------PKVANITVQLEMKALWDEFNQLGTEM 130

  Fly   217 IITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKADPISPPRIHV 281
            |:||.||||||||||:|.|:||.|.|:.:|||||:||||||||||:|.|:|||||||.:|.|:|.
Frog   131 IVTKAGRRMFPTFQVKIFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHY 195

  Fly   282 HPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFHLVYLPPKNASLDENEHSS 346
            ||||||.|:.||||||||||||||||.||:|||||||||||||||||:||:.|:..|  |.....
Frog   196 HPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDS--EKYAEE 258

  Fly   347 HFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRD----DGTNDVTTGGGSSMSSMSHESQ 407
            :|:||:|.||.|||||||||.|:|||||:||||||||||    |...:...|   |:..|:..::
Frog   259 NFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPG---SLPLMNAFAR 320

  Fly   408 ARMKQQQQQQQQQQQQLQQQQQQQQQLKERTAATSNFGLSCSELAIEQQQQQQQQQGVLQLPATP 472
            :|.......|....:....:::.::.    |:.|...|     .|..||...:.....|.:|...
Frog   321 SRNPVSSPPQNGSDKDGDGRREYERD----TSGTPLHG-----DAAHQQLMSRVLSPSLPVPGGL 376

  Fly   473 SSSSTSGNSPDLLGYQMEQQLQQQHQQQQQQQHQSQQQHLHQQH----QANQQQSLLQQSQNHTQ 533
            ...||...||     ..|.:|....|..:...|...:......|    :.......|...:.|
Frog   377 VPLSTGRPSP-----PHELRLDPHSQGSEPLHHHPYKYPTSYDHYLGAKTRPAPYPLPSIRGH-- 434

  Fly   534 YGSYHHAYQAQVQSHPLTPHSSSSASPPATAAPGASAATAAVAGGAGAAGA 584
              .|||        ||:.|                  |.|.:..||||.|:
Frog   435 --GYHH--------HPMNP------------------AAANMYSGAGAPGS 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	138/197 (70%)
tbx1	NP_001030290.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58		8/48 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..103		13/64 (20%)
		T-box	112..297	CDD:366363	135/186 (73%)
		T-box	114..297		134/184 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..354		4/37 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..405		9/42 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I1504
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003320
OrthoInspector	1	1.000	-	-		oto105593
Panther	1	1.100	-	-	O	PTHR11267
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	1	1.000	-	-		X3735
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.130