Protein Alignment org-1 and tbx1

DIOPT Version :10

• Sequence 1: NP_511085.2
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_001030290.1
• Gene: tbx1 / 619587
• XenbaseID: XB-GENE-478084
• Length: 463
• Species: Xenopus tropicalis
• Alignment Length: 571
• Identity: 211/571 - (36%)
• Similarity: 268/571 - (46%)
• Gaps: 143/571 - (25%)

  Fly    22 FLDTSLTDYNCYGNDYWTSPYMTGGLSPMKQIEACIQTAGKDRSSYKPLEQIDAKLADIETHSTG 86
            |...||:..|..|. |..||      ||           |...|.::|             |...
 Frog    22 FTANSLSSLNASGG-YHLSP------SP-----------GDPYSQHEP-------------HYEP 55

  Fly    87 STGTANSNSSTSSISNPSCPDQSSSSSSSSVSLPTDYAGVHSEASMAPTAGGTAVTTTSAGGVSA 151
            .:.:.:|.|     ...:||:..|.:||||.            ||..|.:|.|           .
 Frog    56 CSASQHSYS-----FGHACPEPESGASSSSC------------ASSTPGSGST-----------G 92

  Fly   152 STASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSLAQAIVVLETKALWDQFHAQGTEM 216
            |:.|.|              ..||.|             |.:|...|.||.|||||:|:..||||
 Frog    93 SSGSSK--------------APVKKN-------------PKVANITVQLEMKALWDEFNQLGTEM 130

  Fly   217 IITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKADPISPPRIHV 281
            |:||.||||||||||:|.|:||.|.|:.:|||||:||||||||||:|.|:|||||||.:|.|:|.
 Frog   131 IVTKAGRRMFPTFQVKIFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHY 195

  Fly   282 HPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFHLVYLPPKNASLDENEHSS 346
            ||||||.|:.||||||||||||||||.||:|||||||||||||||||:||:.|:..|  |.....
 Frog   196 HPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDPRKDS--EKYAEE 258

  Fly   347 HFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRD----DGTNDVTTGGGSSMSSMSHESQ 407
            :|:||:|.||.|||||||||.|:|||||:||||||||||    |...:...|   |:..|:..::
 Frog   259 NFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPG---SLPLMNAFAR 320

  Fly   408 ARMKQQQQQQQQQQQQLQQQQQQQQQLKERTAATSNFGLSCSELAIEQQQQQQQQQGVLQLPATP 472
            :|.......|....:....:::.::.    |:.|...|     .|..||...:.....|.:|...
 Frog   321 SRNPVSSPPQNGSDKDGDGRREYERD----TSGTPLHG-----DAAHQQLMSRVLSPSLPVPGGL 376

  Fly   473 SSSSTSGNSPDLLGYQMEQQLQQQHQQQQQQQHQSQQQHLHQQH----QANQQQSLLQQSQNHTQ 533
            ...||...||     ..|.:|....|..:...|...:......|    :.......|...:.|
 Frog   377 VPLSTGRPSP-----PHELRLDPHSQGSEPLHHHPYKYPTSYDHYLGAKTRPAPYPLPSIRGH-- 434

  Fly   534 YGSYHHAYQAQVQSHPLTPHSSSSASPPATAAPGASAATAAVAGGAGAAGA 584
              .|||        ||:.|                  |.|.:..||||.|:
 Frog   435 --GYHH--------HPMNP------------------AAANMYSGAGAPGS 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_511085.2	T-box_TBX1_10-like	195..385	CDD:410313	135/189 (71%)
tbx1	NP_001030290.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..58		8/48 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..103		13/64 (20%)
		T-box_TBX1_10-like	109..297	CDD:410313	135/189 (71%)
		T-box	114..297		134/184 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	320..354		4/37 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	367..405		9/42 (21%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P70323	420..431		1/10 (10%)