DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment org-1 and tbx2a

DIOPT Version :9

Sequence 1:	NP_001285019.1	Gene:	org-1 / 31778	FlyBaseID:	FBgn0021767	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_005165613.1	Gene:	tbx2a / 573084	ZFINID:	ZDB-GENE-990917-4	Length:	690	Species:	Danio rerio

Alignment Length:	561	Identity:	186/561 - (33%)
Similarity:	253/561 - (45%)	Gaps:	140/561 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 GTVKPNSHNISKGESEP-VHPSLA---QAI-------------------VVLETKALWDQFHAQG 213
            |..||.:.:...|.:|. :|.:|.   ||.                   |.||.|.||||||..|
Zfish    46 GLSKPLADHALSGAAEAGLHAALGHHHQAAHLRSFKGLEPEEDVEDDPKVTLEAKELWDQFHKIG 110

  Fly   214 TEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKADPISPPR 278
            |||:|||:||||||.|:||:.|||..|.||.:||.|..||.||:  ||||.|:|||||||..|.|
Zfish   111 TEMVITKSGRRMFPPFKVRVNGLDKKAKYILLMDIVAADDCRYK--FHNSRWMVAGKADPEMPKR 173

  Fly   279 IHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFHLV------YLPPKNA 337
            :::||||||.|..||.:.|:|.|||||||..|::|..||||||:||||||:|      .||
Zfish   174 MYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLP---- 234

  Fly   338 SLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDGTNDVTTGGGSSMSSM 402
                   .|.|||::||||.|.|||||||.::|||||.:|||||||||       ||.|....|:
Zfish   235 -------YSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRD-------TGNGRREKSL 285

  Fly   403 SHESQARMKQQQQQQQQQQQQLQQQQQQQQQLKERTA----------ATS-----------NFGL 446
            :...|..|...:....|.:.............::.|.          |||           ||..
Zfish   286 NFRKQLAMPSMRMYDDQCKVDRDGGDSDDSSCEQTTGRDSVHSPTGPATSPLKFTRSREDKNFNE 350

  Fly   447 SCSELAIEQQQQQQQQQGVL------QLPATPSSSSTSGNSPDLLGYQMEQQLQQQHQQQQQQ-- 503
            |.:||       .|...|::      |.|.:|.|........|.|..:.:.......::....
Zfish   351 SDNEL-------DQHDDGMIRVSSPEQRPQSPFSPRCEDRVKDRLNLEKKGDYSDSRKENDSAFS 408

  Fly   504 -QHQSQQQHLHQQHQANQQQS------------------LLQQSQNHTQYGSYH---HAYQAQVQ 546
             :|..:.: |..::..:|..|                  |:.|::|.:.:.:.|   .|......
Zfish   409 IRHLDKDK-LDARNVKDQDSSKKEADSVGMSTVKDGFSPLMVQTENPSHFSASHLQSLALSGLHN 472

  Fly   547 SHPLTPHSSSSA----------SPPATAAPGASAATAAVAGGAGAAGAGGATSATQVMSAANIYS 601
            .|...|.||..:          :|.|.:..|.....|::   :||:|....:.::|..|:.|.:
Zfish   473 QHFFNPLSSGQSLLFHPGQFAMTPSAFSTMGMGHLLASM---SGASGLENGSLSSQSTSSPNPF- 533

  Fly   602 SIGQPYAQEQ----------SNFGAI----YHHNAAAAAAA 628
                |:...|          ..||.:    |.:.|||||||
Zfish   534 ----PFHLSQHMLASQGISMPTFGGLLPYPYTYMAAAAAAA 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	120/218 (55%)
tbx2a	XP_005165613.1	TBOX	92..277	CDD:238106	118/204 (58%)
tbx2a	XP_005165613.1	TBX	297..372	CDD:204975	13/81 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810