DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment org-1 and tbx1

DIOPT Version :9

Sequence 1:	NP_001285019.1	Gene:	org-1 / 31778	FlyBaseID:	FBgn0021767	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_005168668.1	Gene:	tbx1 / 368206	ZFINID:	ZDB-GENE-030805-5	Length:	519	Species:	Danio rerio

Alignment Length:	521	Identity:	197/521 - (37%)
Similarity:	260/521 - (49%)	Gaps:	119/521 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 DIETHSTGSTGTANSNSSTSSISNPSCPDQSSSSSSSSVSLPT-----DYAGVHSEASMAPTAGG 138
            |:...:|.|..:.|:..|..  .:||..|..|...|.....|.     :|:|  |.::.||..|.
Zfish    77 DVAAFTTSSLSSLNTPGSYH--LSPSPGDPYSHHESQFEPCPAAQHAYNYSG--SNSAQAPAQGD 137

  Fly   139 TAVTTTSAGGVSASTASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSLAQAIVVLETK 203
            :..:..|:.. |:||.:|..               ||.|             |.:|...|.||.|
Zfish   138 SGTSNCSSSS-SSSTPNKTL---------------VKKN-------------PKVANINVQLEMK 173

  Fly   204 ALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVA 268
            ||||:|:..|||||:||.||||||||||:|.|:||.|.|:.:|||:|:||||||||||:|.|:||
Zfish   174 ALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLLMDFLPVDDKRYRYAFHSSSWLVA 238

  Fly   269 GKADPISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFHLVYLP 333
            |||||.:|.|:|.||||||.|:.||||||||||||||||.||:|||||||||||||||||:||:.
Zfish   239 GKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVD 303

  Fly   334 PKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRD----DGTNDVTTG 394
            |:..|  |.....:::||:|.||.|||||||||.|:|||||:||||||||||    |...:...|
Zfish   304 PRKDS--EKYAEENYKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPG 366

  Fly   395 GGSSMSSMSHESQAR--MKQQQQQQQQQQQQLQQQQQQQQQLKERTAATSNFGLSCSELAIEQQQ 457
               |:..||..::.|  |....||...:::..:::..:..                |...:....
Zfish   367 ---SLQIMSAFARTRNPMSSPPQQNGTEKEDSRREYDRDP----------------SGNPLHSDP 412

  Fly   458 QQQQQQGVLQLPATP------SSSSTSG-NSPDLLGYQMEQQLQQQHQQQQQQQHQSQQQHLHQQ 515
            ..|....||. ||.|      :...|:| .||.              .:.:...|......||
Zfish   413 THQLMSRVLS-PALPVLGGLHAVPLTAGPRSPP--------------HELRLDGHPQPPDTLH-- 460

  Fly   516 HQANQQQSLLQQSQNHTQY---GSYHHAYQAQ----------VQSHPLTPHSSSSASP--PATAA 565
                           |..|   .:|.|...|:          ::.|...||.:.:.:.  .||:|
Zfish   461 ---------------HHPYKYPATYEHYLGAKTRPSPYPSPSIRGHGYHPHMNPTTANMYSATSA 510

  Fly   566 P 566
            |
Zfish   511 P 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	136/197 (69%)
tbx1	XP_005168668.1	TBOX	165..355	CDD:238106	135/191 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1514
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003320
OrthoInspector	1	1.000	-	-		oto39786
orthoMCL	1	0.900	-	-		OOG6_107409
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	1	1.000	-	-		X3735
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.800