Protein Alignment org-1 and Tbx1

DIOPT Version :10

• Sequence 1: NP_511085.2
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_001402633.1
• Gene: Tbx1 / 360737
• RGDID: 1307734
• Length: 530
• Species: Rattus norvegicus
• Alignment Length: 663
• Identity: 226/663 - (34%)
• Similarity: 282/663 - (42%)
• Gaps: 209/663 - (31%)

  Fly    75 AKLADIETHSTG---STGTANSNS-STSSISNPSCPDQSSSSSSSSVSLPTDYAGVHSEASMAPT 135
            |||..:.....|   ||.|.:..: :.||:|....|...:.........|..|    ...:.||.
  Rat    39 AKLRRLPGSPAGMHFSTVTRDMEAFAASSLSGLGAPSPGADPFGPREPPPPRY----DPCTAAPG 99

  Fly   136 AGGTAVT------TTSAGGVSASTASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSLA 194
            |.|....      ..:.|..|:|.|..:..|..:.   :|....||.|             |.:|
  Rat   100 APGPPPPPRAYPFAPAPGAASSSAAESEGPGASRA---AAAKAPVKKN-------------PKVA 148

  Fly   195 QAIVVLETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYA 259
            ...|.||.|||||:|:..|||||:||.||||||||||::.|:||.|.|:.:|||||:||||||||
  Rat   149 SVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYA 213

  Fly   260 FHNSCWVVAGKADPISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQ 324
            ||:|.|:|||||||.:|.|:|.||||||.|:.||||||||||||||||.||:|||||||||||||
  Rat   214 FHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQ 278

  Fly   325 PRFHLVYLPPKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDGTN 389
            ||||:||:.|:..|  |.....:|:||:|.||.|||||||||.|:|||||:||||||||||....
  Rat   279 PRFHVVYVDPRKDS--EKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPE 341

  Fly   390 DVTTGGGSSMSSMSHESQARMKQQQQQQQQQQQQLQQQQQQQQQLKERTAATSNFGLSCSELAIE 454
            |
  Rat   342 D---------------------------------------------------------------- 342

  Fly   455 QQQQQQQQQGVLQLPA------TPSSSSTSGNSPDLLGYQMEQQLQQQHQQQQQQQHQSQQQHLH 513
              ..:..:.|.|.|.:      .|.:|.|..|..|          :...:.:::....|....|.
  Rat   343 --WPRNHRPGALPLVSAFARSRNPVASPTQPNGAD----------KDVAEARREFDRDSGPAALG 395

  Fly   514 QQHQANQQQSLLQQSQNHTQYGSYHHAYQAQVQSHPLTPHSSSSASPPATAAPGASAATAAVAGG 578
            .                               .:||  |...:....||...||   ....:.||
  Rat   396 D-------------------------------ATHP--PQLLARVLSPALPGPG---GLVPLPGG 424

  Fly   579 AGAAGAGGATSATQVMSAANIYSSIGQPYAQEQSNFGAIYHH--NAAAAAAAHY----------- 630
            :|  |......|...:.|         |.|.|     .::||  ...|||..||
  Rat   425 SG--GRHSPPHADLRLEA---------PGASE-----PLHHHPYKYPAAAYDHYLGAKSRPAPYP 473

  Fly   631 --------HHGHAHGHAHSHAHAH-AHGPYASAYDKLKVSRHAAAAAYGMGATYPSFYGSAAHHQ 686
                    :|.|||.|||.|.|.| |..|.|:|         |||||       .:.|.|||
  Rat   474 LPGLRGHGYHPHAHPHAHPHHHHHPAVNPAAAA---------AAAAA-------ANVYSSAA--- 519

  Fly   687 MMRPNSYIDLVPR 699
             ..|.:| |..||
  Rat   520 -APPGAY-DYCPR 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_511085.2	T-box_TBX1_10-like	195..385	CDD:410313	134/189 (71%)
Tbx1	NP_001402633.1	T-box_TBX1_10-like	150..337	CDD:410313	134/188 (71%)