Protein Alignment org-1 and Eomes

DIOPT Version :10

• Sequence 1: NP_511085.2
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_001414322.1
• Gene: Eomes / 316052
• RGDID: 1359706
• Length: 708
• Species: Rattus norvegicus
• Alignment Length: 680
• Identity: 179/680 - (26%)
• Similarity: 253/680 - (37%)
• Gaps: 186/680 - (27%)

  Fly    85 TGSTGTANSNSSTSSISN-----PSCPDQSSSSSSSSVSL---PTDYAGVHSE------------ 129
            :.:|..|.:..|..|:|:     || |....|..::..||   |......|..
  Rat   127 SAATAAATARYSMDSLSSERYYLPS-PGPQGSELAAPCSLFQYPAAAGAAHGSVYPASNGARYPY 190

  Fly   130 ASMAPTAG-GTAVTTTSAGGVSASTASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSL 193
            .||.|..| ..||...:......:|.|....|       |:..|...|..:  ..|:..|::...
  Rat   191 GSMLPPGGFPAAVCPPARSQFGPATGSGSGAG-------SSGGGAGGPGGY--PYGQGSPLYGPY 246

  Fly   194 A---------------------QAIVVLETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLD 237
            |                     :|.|.|..:.||.:||...|||||||.||||||.....|.||:
  Rat   247 AGTSAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLN 311

  Fly   238 PHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKAD-PISPPRIHVHPDSPAVGSNWMKQIVSFDK 301
            |.|.|...::.|..|...:|  |....||..|||| .:...:::|||:||..||:||:|.:||.|
  Rat   312 PTAHYNVFVEVVLADPNHWR--FQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGK 374

  Fly   302 LKLTNNQLDENGH---IILNSMHRYQPRFHLVYLPPKNASLDENEHSSHFRTFIFPETSFTAVTA 363
            ||||||:...|.:   |:|.|:|:||||.|:|.:...... |.|| .|..:||.|.||.|.||||
  Rat   375 LKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVE-DLNE-PSKTQTFTFSETQFIAVTA 437

  Fly   364 YQNQRVTQLKISSNPFAKGFRDDGTNDVTTGGGSSMSSMSHESQARMKQQQQQQQQQQQQLQQQQ 428
            |||..:|||||..|||||||||:..:..|......::....:|                     .
  Rat   438 YQNTDITQLKIDHNPFAKGFRDNYDSMYTASENDRLTPSPTDS---------------------P 481

  Fly   429 QQQQQLKERTAATSNFGLSCSELAIEQQQQQQQQQGVLQLPATPSSSSTSGNSPDLLGYQMEQQL 493
            :..|.:........||   ..|..:....|.:...|...:|      .|:|    ||..|..:::
  Rat   482 RSHQIVPGGRYGVQNF---FPEPFVNTLPQARYYNGERTVP------QTNG----LLSPQQSEEV 533

  Fly   494 QQQHQQQQQQQHQSQQQHLHQQHQANQQQSLL-----QQSQNHTQYGSYHHAYQAQ------VQS 547
                                    ||..|..|     |...|....|||...|.:.      ::|
  Rat   534 ------------------------ANPPQRWLVTPVQQPVTNKLDIGSYESEYSSSTLLPYGIKS 574

  Fly   548 HPL-TPHSSSSASPPATAAPGASAATAAVAGGAGAAGAGGATSATQVMSAANIYSSIGQP--YAQ 609
            .|| |.|:......|...|               .||.||..:..:.|:|...::|...|  :.:
  Rat   575 LPLQTSHALGYYPDPTFPA---------------MAGWGGRGAYQRKMAAGLPWTSRMSPPVFPE 624

  Fly   610 EQ-------------------------SNFGAIYHHNAAAAAAAHYHHGHAHGHAHSHAHAHAHG 649
            :|                         ||...:|  |:|.          ..........::.:.
  Rat   625 DQLAKEKVKEEISSSWVETPPSIKSLDSNDSGVY--NSAC----------KRKRLSPTTSSNGNS 677

  Fly   650 PYASAYDKLKVSRHAAAAAYGMGATYPSFY 679
            |.....| :....::...:.||||.| :||
  Rat   678 PPIKCED-INTEEYSKDTSKGMGAYY-AFY 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_511085.2	T-box_TBX1_10-like	195..385	CDD:410313	95/193 (49%)
Eomes	NP_001414322.1	None