DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment org-1 and bi

DIOPT Version :9

Sequence 1:	NP_001285019.1	Gene:	org-1 / 31778	FlyBaseID:	FBgn0021767	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001259238.1	Gene:	bi / 31379	FlyBaseID:	FBgn0000179	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	223/828 - (26%)
Similarity:	309/828 - (37%)	Gaps:	298/828 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 THSTGSTGTANSNSSTSSISN---------------------------PSCPDQSSSSSSSSVSL 119
            ||:..:..|.|:|::.::.|.                           |..|..::||||||
  Fly   123 THNNNNNHTNNNNNNNNNTSQKQGHHLSTTEEPPSPAGTPPPTIVGLPPIPPPNNNSSSSSS--- 184

  Fly   120 PTDYAGVHSEASMAPTAG------GTAVTTTSAGGVSASTASKKFKGQHKKDNNSA--------- 169
             .:.|...:..|..|||.      |.|.....|.|:...|.....:.|.::..:.|
  Fly   185 -NNSASAAAHPSHHPTAAHHSPSTGAAAPPAGATGLPPPTPPHHLQQQQQQQQHPAPPPPPYFPA 248

  Fly   170 ------------------ENGTVK---------PNSHN------------ISKGESEPVHPSL-- 193
                              ..|.::         |::|:            ::...:..:||::
  Fly   249 AALAALAGSPAGPHPGLYPGGGLRFPPHHPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRP 313

  Fly   194 AQAI------------VVLETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMM 246
            .:|:            |.||.|.||::||..||||:|||:||:|||..:.|:.|||..|.||.::
  Fly   314 LRALQPEDDGVVDDPKVTLEGKDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLL 378

  Fly   247 DFVPMDDKRYRYAFHNSCWVVAGKADPISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDE 311
            |.|..||  |||.||||.|:|||||||..|.|:::|||||..|..||:::|||.|||||||..|:
  Fly   379 DIVAADD--YRYKFHNSRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDK 441

  Fly   312 NGHI---ILNSMHRYQPRFHLV------YLPPKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQ 367
            :|.:   ||||||:||||||||      .||           .|.|||::|.||.|.|||||||:
  Fly   442 HGFVSTTILNSMHKYQPRFHLVRANDILKLP-----------YSTFRTYVFKETEFIAVTAYQNE 495

  Fly   368 RVTQLKISSNPFAKGFRDDGTNDVTTGGGSSMSSMSHESQARMKQQQQQQQQQQQQLQQQQQQQQ 432
            ::|||||.:|||||||||       ||.|                   :::::|..:..:.....
  Fly   496 KITQLKIDNNPFAKGFRD-------TGAG-------------------KREKKQALMSNRGSDSD 534

  Fly   433 QLKERTAATSNFGLSCS----------ELAIEQQQQQQQQQ-----GVLQLPATPSSSSTSGNSP 482
            :|.....::|...|...          ..|:...||....:     |..|.|..|.|
  Fly   535 KLNPTHVSSSRAPLHLGHAGRPPHLHPHAALLDNQQDDDDKLLDVVGPPQSPLLPLS-------- 591

  Fly   483 DLLGYQMEQQLQQQHQQQQQQQHQSQQQHLHQQHQANQQQSLLQQSQNH---TQYGSYHHAYQA- 543
                                  |..||.|.||...|      |....||   ...|:..||..|
  Fly   592 ----------------------HSLQQMHAHQHSAA------LAAWFNHLAGAGAGASEHAAAAA 628

  Fly   544 -------------QVQSHPLTPHSSSSAS------------PPATAAPGASAATAAVAGGAGAAG 583
                         |..:......|.||.|            |.:|.:|..:...||.|..||...
  Fly   629 ANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEAVGAAAAAAAAGLNP 693

  Fly   584 AGGATSATQVMSAANIYSSIGQPYAQEQSNFGAIY--------H----HNAAAAAAAH------- 629
            .||:..:..:        |:|.|..........:|        |    ||.|||||..
  Fly   694 GGGSYPSPNI--------SVGPPIHPSPHLLPYLYPHGLYPPPHLGLLHNPAAAAAMSPAGLNPG 750

  Fly   630 ----------YHHGHAHGHAHSHA-----------HAHAHGPYA------SAYDKLKVSRHA--- 664
                      ..|....|||::.|           .:|...||:      ||:|.:....:|
  Fly   751 LLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQGLKSHRFSPYSLPGSLGSAFDAVTPGSNANRS 815

  Fly   665 ----AAAAYGMGA----TYPSFYGS------AAHHQMMRPNSYIDLVP 698
                .....|:|.    ..|....|      |:|....||.|.....|
  Fly   816 GDPPGGGGGGLGGGVVENGPRSLSSSPRPRPASHSPPTRPISMSPTTP 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	114/214 (53%)
bi	NP_001259238.1	Optomotor-blind	<260..318	CDD:287988	6/57 (11%)
bi	NP_001259238.1	T-box	330..513	CDD:279278	111/195 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439060
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2837
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.870