Protein Alignment org-1 and Tbx2

DIOPT Version :10

• Sequence 1: NP_511085.2
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_001388735.1
• Gene: Tbx2 / 303398
• RGDID: 1311014
• Length: 711
• Species: Rattus norvegicus
• Alignment Length: 629
• Identity: 203/629 - (32%)
• Similarity: 272/629 - (43%)
• Gaps: 147/629 - (23%)

  Fly   134 PTAGGTAVTTTSAGGVSASTASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSLAQAIV 198
            |...|.|....:|...:.:.......|.|            .|.:|..|....||.........|
  Rat    55 PGLAGAAAAAAAAAAAAEAGLHVSALGPH------------PPAAHLRSLKSLEPEDEVEDDPKV 107

  Fly   199 VLETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNS 263
            .||.|.||||||..||||:|||:||||||.|:||:.|||..|.||.:||.|..||.||:  ||||
  Rat   108 TLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYK--FHNS 170

  Fly   264 CWVVAGKADPISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFH 328
            .|:|||||||..|.|:::||||||.|..||.:.|:|.|||||||..|::|..||||||:||||||
  Rat   171 RWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFH 235

  Fly   329 LV------YLPPKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDG 387
            :|      .||           .|.|||::||||.|.|||||||.::|||||.:|||||||||.|
  Rat   236 IVRANDILKLP-----------YSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTG 289

  Fly   388 T------NDVT--------------TGGGSSMSSMSHESQAR------------MKQQQQQQQQQ 420
            .      ..:|              ..|..|.:|......||            ::..:.:.:::
  Rat   290 NGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSCDPPPAREPPPSPSAAPSPLRLHRARAEEK 354

  Fly   421 QQQLQQQQQQQQQLKERTAATSNFGLSCSELAIEQQQQQQQQQGVLQLPATPSSSSTSGNSP--- 482
            ........:.::..:||.||.  .|.|.|..|...:..:.::....:.|...|...|.|...
  Rat   355 PCAADSDPEPERSGEERAAAP--LGRSSSRDASPARLTEPERSRERRSPERGSKEPTEGGGDGPF 417

  Fly   483 DLLGYQMEQQLQQQHQQQQQQQHQSQQQHLHQQHQANQQQSLLQQSQNHTQYGSYH--------H 539
            .|...:.|:...::..:.::...:.::..|         ..|:.|:.:.:..|:.|        |
  Rat   418 SLRSLEKERAEARRKDEGRKDVGEGKEPSL---------APLVVQTDSASPLGAGHLPGLAFSSH 473

  Fly   540 AYQAQV-----QSHPLTPHSSSSA-SPPATAAPGASAATAAVAGGAGAAG-----------AGGA 587
            .:..|.     ...||..|....| .|.|.:|.|.....|:||||.|.:|           |||.
  Rat   474 LHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGMGHLLASVAGGGGNSGGAAPGTAAGLDAGGL 538

  Fly   588 TSATQVMSAA---------NIYSSIGQPYAQEQSNFGAI----YHHNAAAAAAAHYHHGHAHGHA 639
            ..|....|.|         ::.:|.|.|    ...||.:    |.:.|||||||
  Rat   539 GPAASAASTATPFPFHLSQHMLASQGIP----MPTFGGLFPYPYTYMAAAAAAA----------- 588

  Fly   640 HSHAHAHAHGPYASAYDKLKVSRHAAAAAYGMGATYPS-FYGSA 682
                            ..|..:..|||||...|:...| |.|||
  Rat   589 ----------------SALPATSAAAAAAAAAGSLSRSPFLGSA 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_511085.2	T-box_TBX1_10-like	195..385	CDD:410313	116/195 (59%)
Tbx2	NP_001388735.1	T-box_TBX2_3-like	103..287	CDD:410314	116/196 (59%)
		TBX	305..379	CDD:432659	10/75 (13%)