DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment org-1 and Mga

DIOPT Version :9

Sequence 1:	NP_001285019.1	Gene:	org-1 / 31778	FlyBaseID:	FBgn0021767	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_006499750.1	Gene:	Mga / 29808	MGIID:	1352483	Length:	3091	Species:	Mus musculus

Alignment Length:	453	Identity:	143/453 - (31%)
Similarity:	205/453 - (45%)	Gaps:	116/453 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 MAPTAGGTAVTTTSAGGVSASTASKKFKGQHKKDNNSAENGTVKPN-------SHNISKGESE-- 187
            :|...|||.     .||........|..|     |...:.|.:..|       |...|.|:|:
Mouse     9 LANQDGGTV-----TGGAPTFFVILKQPG-----NGKTDQGILVTNRDARALLSRESSPGKSKEK 63

  Fly   188 ---PVHPSLAQAIVVLETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFV 249
               |...::.:..|.|:..::|::||.:.||||:||.||||||..:..|.|||.:..||.:||..
Mouse    64 ICLPADCTVGKITVTLDNNSMWNEFHNRSTEMILTKQGRRMFPYCRYWITGLDSNLKYILVMDIS 128

  Fly   250 PMDDKRYRYAFHNSCWVVAGKADPISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGH 314
            |:|..||::  :...|..:|||:|....|:.:||:||:.|..||.|.|||.|||||||.||:.||
Mouse   129 PVDSHRYKW--NGRWWEPSGKAEPHILGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQEGH 191

  Fly   315 IILNSMHRYQPRFHLVYLPPKNAS--LDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSN 377
            |||:|||||.||.|||  |.:.|:  :..|....|  ||.||:|.|.|||||||.::|||||..|
Mouse   192 IILHSMHRYLPRLHLV--PAEKATEVIQLNGPGVH--TFTFPQTEFFAVTAYQNIQITQLKIDYN 252

  Fly   378 PFAKGFRDDGTND----------------------------VTTGGGSSMSS-------MSHESQ 407
            ||||||||||.:.                            :|.|.||.:.|       ..||:.
Mouse   253 PFAKGFRDDGLSSKPQREGKQRNSSDQEGNSVSSSPAHRVRLTEGEGSEIHSGDFDPVLRGHEAS 317

  Fly   408 A--------RMKQQ--------------QQQQQQQQQQLQQQQQQQQQLKERTAATSNFGL---- 446
            :        .:||.              |.:.:..:.::....:...|:...:....||.:
Mouse   318 SLSLEKAPHNVKQDFLGFMNTDSTHEVPQLKHEISESRIVNSFEDDSQISSPSNPNGNFNVVIKE 382

  Fly   447 -----------SCSELAIEQQQQQQQQQGVLQLPATPSSSSTSGNSPDLLGYQMEQQLQQQHQ 498
                       .|.|....:|::..::..|.         |.|.:.|.|     |:||::.::
Mouse   383 EPLDDYDYELGECPEGITVKQEETDEETDVY---------SNSDDDPIL-----EKQLKRHNK 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	103/195 (53%)
Mga	XP_006499750.1	TBOX	74..264	CDD:238106	103/195 (53%)
		DUF4801	1038..1080	CDD:374336
		DUF5585	<1510..>1811	CDD:375359
		Atrophin-1	1729..>2023	CDD:367360
		bHLHzip_MGA	2452..2516	CDD:381481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1201455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920