DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment org-1 and MGA

DIOPT Version :9

Sequence 1:	NP_001285019.1	Gene:	org-1 / 31778	FlyBaseID:	FBgn0021767	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_005254300.1	Gene:	MGA / 23269	HGNCID:	14010	Length:	3115	Species:	Homo sapiens

Alignment Length:	323	Identity:	128/323 - (39%)
Similarity:	172/323 - (53%)	Gaps:	20/323 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 GGVSASTASKKFKGQHKKDNNSAENGTVKPN-----------SHNISKGE-SEPVHPSLAQAIVV 199
            ||..|..|...|....:..|...:.|.:..|           |...|||: ..|...::....|.
Human    14 GGTVAGAAPTFFVILKQPGNGKTDQGILVTNQDACALASSVSSPVKSKGKICLPADCTVGGITVT 78

  Fly   200 LETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSC 264
            |:..::|::|:.:.||||:||.||||||..:..|.|||.:..||.:||..|:|:.||::  :...
Human    79 LDNNSMWNEFYHRSTEMILTKQGRRMFPYCRYWITGLDSNLKYILVMDISPVDNHRYKW--NGRW 141

  Fly   265 WVVAGKADPISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFHL 329
            |..:|||:|....|:.:||:||:.|..||.|.|||.|||||||.||:.|||||:|||||.||.||
Human   142 WEPSGKAEPHVLGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHL 206

  Fly   330 VYLPPKNA--SLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDGTNDVT 392
            |  |.:.|  .:..|....|  ||.||:|.|.|||||||.::|||||..|||||||||||.|:..
Human   207 V--PAEKAVEVIQLNGPGVH--TFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRDDGLNNKP 267

  Fly   393 TGGGSSMSSMSHESQARMKQQQQQQQQQQQQLQQQQQQQQQLKERTAATSNFGLSCSELAIEQ 455
            ...|...:|...|..........:.:..:.|..:.|........|...||..||..:.|.|::
Human   268 QRDGKQKNSSDQEGNNISSSSGHRVRLTEGQGSEIQPGDLDPLSRGHETSGKGLEKTSLNIKR 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	102/195 (52%)
MGA	XP_005254300.1	TBOX	74..264	CDD:238106	102/195 (52%)
		DUF4801	1041..1087	CDD:292677
		HLH	2475..2525	CDD:278439
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1201455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920