Protein Alignment org-1 and Tbx3

DIOPT Version :10

• Sequence 1: NP_511085.2
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_035665.2
• Gene: Tbx3 / 21386
• MGIID: 98495
• Length: 741
• Species: Mus musculus
• Alignment Length: 720
• Identity: 213/720 - (29%)
• Similarity: 291/720 - (40%)
• Gaps: 192/720 - (26%)

  Fly    97 TSSISNPSCPDQSSSSSSSSVSLPTDYAGVHSEASMAPTAGGTAVTTTSAGGVSASTASKKFKGQ 161
            ||...:|..|.::...:.|:|   ..:......|...|..|..|:   |..|..|.....:..|
Mouse    13 TSMAYHPFLPHRAPDFAMSAV---LGHQPPFFPALTLPPNGAAAL---SLPGALAKPIMDQLVG- 70

  Fly   162 HKKDNNSAENG----TVKPNSHNISKGESEPVHPSLAQAIVVLETKALWDQFHAQGTEMIITKTG 222
                  :||.|    ::.|.:|.......||.........|.||.|.||||||.:||||:|||:|
Mouse    71 ------AAETGIPFSSLGPQAHLRPLKTMEPEEDVEDDPKVHLEAKELWDQFHKRGTEMVITKSG 129

  Fly   223 RRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKADPISPPRIHVHPDSPA 287
            |||||.|:||..|||..|.||.:||.:..||.||:  ||||.|:|||||||..|.|:::||||||
Mouse   130 RRMFPPFKVRCSGLDKKAKYILLMDIIAADDCRYK--FHNSRWMVAGKADPEMPKRMYIHPDSPA 192

  Fly   288 VGSNWMKQIVSFDKLKLTNNQLDENG--------------------HIILNSMHRYQPRFHLV-- 330
            .|..||.::|:|.|||||||..|::|                    ..||||||:||||||:|
Mouse   193 TGEQWMSKVVTFHKLKLTNNISDKHGFTLAFPSDHATWQGNYSFGTQTILNSMHKYQPRFHIVRA 257

  Fly   331 ----YLPPKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDGTNDV 391
                .||           .|.|||::||||.|.|||||||.::|||||.:|||||||||
Mouse   258 NDILKLP-----------YSTFRTYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRD------ 305

  Fly   392 TTGGGSSMSSMSHESQARMKQQQQQQQQQQQQLQQQQQQQQQLKERTA---------------AT 441
             ||.|         .:.:.||...|..:..::..:::...:...|:.|               .|
Mouse   306 -TGNG---------RREKRKQLTLQSMRVFEERHKKETSDESSSEQAAFNCFAQASSPAVSIVGT 360

  Fly   442 SNFGLSC-SELAIEQQQQQQQQQGV--------------------------LQL-PATPS----- 473
            ||....| ||...:.:.:.:::.|.                          .|| ||.||
Mouse   361 SNLKDLCPSEAESDAEAESKEEHGPEACDAAKISTTTAEEPGRDKGSPATRAQLFPAEPSRARDT 425

  Fly   474 -----SSSTSGNSPDLLGYQMEQQLQQQHQQQQQQ---QHQSQQQHLHQQHQANQQQSLLQQSQN 530
                 :|..|.:||..:..........:.:...::   ..:..:........|....|:...:..
Mouse   426 ARLDKASPDSRHSPATISSSTRVPGADERRSPGREGPVATKVDEARAIPAKDAFAPLSVQTDATA 490

  Fly   531 HTQYGSYHH-------AYQAQVQSHPLTPH----------SSSSA--SPPATAAPGASAA----- 571
            |...|....       |.|.....|||..|          ||.:|  .|......|||..
Mouse   491 HLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPGQFAMGGAFSSMAAGMGPLLATVSGASTGVSGLE 555

  Fly   572 TAAVAGGAGAAGAGGATSAT-------QVMSAANIYSSIGQPYAQEQSNFGAI----YHHNAAAA 625
            :.|:|..|.|.|..||::||       .|:::..:          ..|.||::    |.:.||||
Mouse   556 STAMASAAAAQGLSGASAATLPFHLQQHVLASQGL----------AMSPFGSLFPYPYTYMAAAA 610

  Fly   626 AAAHYHHGHAHGHAHSHAHAH------------AHGPYASAYDKLKVSRHAAAAAYGMGATYPSF 678
            ||       :...|.|..|.|            .:.||:........|...|.|...|.:.....
Mouse   611 AA-------STAAASSSVHRHPFLNLNSMRPRLRYSPYSIPVPVPDSSSLLATALPSMASAAGPL 668

  Fly   679 YGSAA 683
            .|.||
Mouse   669 DGKAA 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_511085.2	T-box_TBX1_10-like	195..385	CDD:410313	115/215 (53%)
Tbx3	NP_035665.2	T-box_TBX2_3-like	101..305	CDD:410314	115/216 (53%)
		TBX	323..402	CDD:432659	9/78 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	369..469		13/99 (13%)