Protein Alignment org-1 and Tbx2

DIOPT Version :10

• Sequence 1: NP_511085.2
• Gene: org-1 / 31778
• FlyBaseID: FBgn0021767
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_033350.2
• Gene: Tbx2 / 21385
• MGIID: 98494
• Length: 711
• Species: Mus musculus
• Alignment Length: 629
• Identity: 203/629 - (32%)
• Similarity: 275/629 - (43%)
• Gaps: 147/629 - (23%)

  Fly   134 PTAGGTAVTTTSAGGVSASTASKKFKGQHKKDNNSAENGTVKPNSHNISKGESEPVHPSLAQAIV 198
            |...|.|....:|...:.:.......|.|            .|.:|..|....||.........|
Mouse    55 PGLAGAAAAAAAAAAAAEAGLHVSALGPH------------PPAAHLRSLKSLEPEDEVEDDPKV 107

  Fly   199 VLETKALWDQFHAQGTEMIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNS 263
            .||.|.||||||..||||:|||:||||||.|:||:.|||..|.||.:||.|..||.||:  ||||
Mouse   108 TLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYK--FHNS 170

  Fly   264 CWVVAGKADPISPPRIHVHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFH 328
            .|:|||||||..|.|:::||||||.|..||.:.|:|.|||||||..|::|..||||||:||||||
Mouse   171 RWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFH 235

  Fly   329 LV------YLPPKNASLDENEHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDG 387
            :|      .||           .|.|||::||||.|.|||||||.::|||||.:|||||||||.|
Mouse   236 IVRANDILKLP-----------YSTFRTYVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTG 289

  Fly   388 T------NDVT--------------TGGGSSMSSMSHESQAR------------MKQQQQQQQQQ 420
            .      ..:|              ..|..|.:|......||            ::..:.:.:::
Mouse   290 NGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSCDPPPAREPPPSPSAAPSPLRLHRARAEEK 354

  Fly   421 QQQLQQQQQQQQQLKERTAATSNFGLSCSELAIEQQQQQQQQQGVLQLPATPSSSSTSGNSP--- 482
            ........:.::..:||:||.  .|.|.|..|...:..:.::....:.|...|...|.|...
Mouse   355 PGAADSDPEPERTGEERSAAP--LGRSPSRDASPARLTEPERSRERRSPERCSKEPTEGGGDGPF 417

  Fly   483 DLLGYQMEQQLQQQHQQQQQQQHQSQQQHLHQQHQANQQQSLLQQSQNHTQYGSYH--------H 539
            .|...:.|:...::..:.::...:.::..|         ..|:.|:.:.:..|:.|        |
Mouse   418 SLRSLEKERPEARRKDEGRKDVGEGKEPSL---------APLVVQTDSASPLGAGHLPGLAFSSH 473

  Fly   540 AYQAQV-----QSHPLTPHSSSSA-SPPATAAPGASAATAAVAGGAGAAG-----------AGGA 587
            .:..|.     ...||..|....| .|.|.:|.|.....|:||||:|::|           |||.
Mouse   474 LHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGMGHLLASVAGGSGSSGGAGPGTAAGLDAGGL 538

  Fly   588 TSATQVMSAA---------NIYSSIGQPYAQEQSNFGAI----YHHNAAAAAAAHYHHGHAHGHA 639
            ..|....|.|         ::.:|.|.|    ...||.:    |.:.|||||||
Mouse   539 GPAASAASTAAPFPFHLSQHMLASQGIP----MPTFGGLFPYPYTYMAAAAAAA----------- 588

  Fly   640 HSHAHAHAHGPYASAYDKLKVSRHAAAAAYGMGATYPS-FYGSA 682
                            ..|..:..|||||...|:...| |.|||
Mouse   589 ----------------SALPATSAAAAAAAAAGSLSRSPFLGSA 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_511085.2	T-box_TBX1_10-like	195..385	CDD:410313	116/195 (59%)
Tbx2	NP_033350.2	T-box_TBX2_3-like	103..287	CDD:410314	116/196 (59%)
		TBX	305..380	CDD:432659	10/76 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	313..449		20/146 (14%)
		Repression domain 1 (RD1). /evidence=ECO:0000250	518..602		27/114 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..687