DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment org-1 and Tbx10

DIOPT Version :9

Sequence 1:	NP_001285019.1	Gene:	org-1 / 31778	FlyBaseID:	FBgn0021767	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001001320.1	Gene:	Tbx10 / 109575	MGIID:	1261436	Length:	385	Species:	Mus musculus

Alignment Length:	352	Identity:	158/352 - (44%)
Similarity:	201/352 - (57%)	Gaps:	66/352 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 HKKDNNSAEN--GTVKPNSHNISKGESE---------PVHPSLAQAIVVLETKALWDQFHAQGTE 215
            |.:.:.|.|:  ||..|:.......|::         |.:|.::..:|.||.|.||::|:..|||
Mouse    20 HPETSTSWESRLGTRFPSGSCTMSTEAQAMAEPTGQGPKNPRVSSVMVQLEMKPLWEEFNQLGTE 84

  Fly   216 MIITKTGRRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKADPISPPRIH 280
            ||:||.||||||||||:|.|:|..|.|..:|||:|:||||||||||:|.|:|||||||.:|.|:|
Mouse    85 MIVTKAGRRMFPTFQVKILGMDTLADYALLMDFIPLDDKRYRYAFHSSAWLVAGKADPATPGRVH 149

  Fly   281 VHPDSPAVGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFHLVYLPPKNAS---LDEN 342
            .||||||.|:.||:|||||||||||||.:|:|||||||||||||||||:|::.|:..|   ..||
Mouse   150 FHPDSPAKGAQWMRQIVSFDKLKLTNNLMDDNGHIILNSMHRYQPRFHVVFVDPRKDSARYAQEN 214

  Fly   343 EHSSHFRTFIFPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDGTN----------DVTTGGGS 397
                 |::|:|.||.|||||||||.|:|||||:|||||||||:...:          .:.....|
Mouse   215 -----FKSFVFTETQFTAVTAYQNHRITQLKIASNPFAKGFREADPDSWPVTPRPLLSIPARSRS 274

  Fly   398 SMSSMSHESQARMKQQQQQQQQQQQQLQQQQQQQQQLKERTAATSNFGLSCSELAIEQQQQQQQQ 462
            |:|....:..|                           ||...||....|.|....:...|....
Mouse   275 SLSPCLLKGSA---------------------------EREKDTSKASASSSRTPTQPHNQLLPA 312

  Fly   463 QGVLQLPAT----------PSSSSTSG 479
            ..||..|||          |.|.|.:|
Mouse   313 PDVLLAPATYRPLPYQNLYPGSPSRAG 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	129/196 (66%)
Tbx10	NP_001001320.1	TBOX	67..254	CDD:238106	129/191 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..310		8/53 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..359		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I1551
eggNOG	1	0.900	-	-		E1_KOG3585
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	330	1.000	Inparanoid score	I2426
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003320
OrthoInspector	1	1.000	-	-		otm44359
orthoMCL	1	0.900	-	-		OOG6_107409
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3735
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820