DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment org-1 and tbx5b

DIOPT Version :9

Sequence 1:	NP_001285019.1	Gene:	org-1 / 31778	FlyBaseID:	FBgn0021767	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001185700.1	Gene:	tbx5b / 100004161	ZFINID:	ZDB-GENE-060601-2	Length:	422	Species:	Danio rerio

Alignment Length:	410	Identity:	146/410 - (35%)
Similarity:	207/410 - (50%)	Gaps:	67/410 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 KKDNNSAENGTVKPNSHNISKGESEPVHPSLAQAI-----VVLETKALWDQFHAQGTEMIITKTG 222
            ::|.:|..:|.        :|..|.|:...|:|..     |.|..|.||.:||...|||||||.|
Zfish    23 ERDKDSGHHGR--------NKTGSPPLQTQLSQQSMEGIKVYLHEKDLWAKFHDVTTEMIITKAG 79

  Fly   223 RRMFPTFQVRIGGLDPHATYICMMDFVPMDDKRYRYAFHNSCWVVAGKADPISPPRIHVHPDSPA 287
            |||||:::|::.||:|.|.||.:||.:..|:.||::|  ::.|.::|||:|..|.|::|||||||
Zfish    80 RRMFPSYKVKVTGLNPKAKYILLMDIISADEHRYKFA--DNKWSISGKAEPAIPGRLYVHPDSPA 142

  Fly   288 VGSNWMKQIVSFDKLKLTNNQLDENGHIILNSMHRYQPRFHLVYLPPKNASLDENEHSSHFRTFI 352
            .|::||:|:|||.|||||||.||..|||||||||:||||.|:|....:|:....|   :.|.|..
Zfish   143 SGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADERNSFGSSN---TSFCTHS 204

  Fly   353 FPETSFTAVTAYQNQRVTQLKISSNPFAKGFRDDGTNDVTTGGGSSMSSMSHESQARMKQQQQQQ 417
            |.||:|.|||:|||..:|||||.:||||||||  |.:|:.....|...|..:....|...:|:..
Zfish   205 FAETTFIAVTSYQNHTITQLKIENNPFAKGFR--GNDDIELHRMSRTPSKEYPLVPRSTARQRAA 267

  Fly   418 QQQQQQLQQQQQQQQQLKERTAATSNFGLSCSELAIEQQQQQQQQQGVLQLPATPSSSSTSGNSP 482
            ......|.:.:....|       ..:.|.:||:.:.:|           .|..|||.     :.|
Zfish   268 PPSPDCLSRSEYTVTQ-------KPSPGFTCSDTSGDQ-----------SLTETPSI-----HDP 309

  Fly   483 --DLLGYQMEQQLQQQHQQQQQQQ---HQSQQQHLHQQHQANQQQSLLQQSQNHTQYGSYHHAYQ 542
              .|..||:...:........|.|   :...|..:.:...|:...|        |.|.|:..|.:
Zfish   310 TYPLFSYQLSPDVAPSSMDTTQHQPCMYGGSQVGMEELRWASYSDS--------TTYQSFSSAKE 366

  Fly   543 AQVQSHPLTPHSSSSASPPA 562
                       .|.:..|||
Zfish   367 -----------MSGTFVPPA 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
org-1	NP_001285019.1	TBOX	195..389	CDD:238106	107/198 (54%)
tbx5b	NP_001185700.1	TBOX	52..240	CDD:238106	106/194 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003320
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010