DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment POTED and Poted

DIOPT Version :9

Sequence 1:NP_778146.2 Gene:POTED / 317754 HGNCID:23822 Length:584 Species:Homo sapiens
Sequence 2:XP_001079298.3 Gene:Poted / 691693 RGDID:9472036 Length:363 Species:Rattus norvegicus


Alignment Length:366 Identity:119/366 - (32%)
Similarity:174/366 - (47%) Gaps:64/366 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   109 CRGSGKSNVGAWGD-----------YDHSAFM-EPRYHIRREDLDKLHRAAWWGKVPRKDLIVML 161
            |.|.||..  .|.|           ||:...: :|.        ::.|.|...|||.....::..
  Rat    24 CDGPGKRI--EWKDCLACRCETADKYDYDLLLYDPD--------NEFHSAVCLGKVSEVQSLLKE 78

Human   162 RDTDMNKRDKEKRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAIQCQEDECVLMLL 226
            :..::|.||...|||||.||..|.:|:|.:|::..|::|.|||:|.|.||||:|..|:..|.:||
  Rat    79 KKYNVNDRDGNNRTALHFASCYGKAEIVNILMENDCEINALDNQKTTPLIKAVQMCEENIVSLLL 143

Human   227 EHGADRNIPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKCGLTPLLLGVHEQKQQVVKFL 291
            |||||.||.|..||||||||:|.....:|..||.|||:||.|.|.|.:||||.:.|.:..:.:||
  Rat   144 EHGADPNIKDANGNTALHYAVYVGKPAIAANLLPYGANIEEKTKDGFSPLLLALRENQLLMAEFL 208

Human   292 IKKKANLNVLDRYGRTALILAVCCGSASIVNLLLEQNVDVSSQDLSGQTAREYAVSSHHHVICEL 356
            |::.|::||.|...||.|:.||...|..:|:|||..|:||..:|.....|..||:..|..|...:
  Rat   209 IRRGADINVSDEQQRTTLMYAVKSDSKRLVDLLLNLNIDVFLKDSFSWNALRYAIMGHRKVARTI 273

Human   357 L-------------------SDYKEKQMLKISSENSN---PEQDLKLTSEEESQRLKVSENSQPE 399
            |                   .|:...:.|..|...:|   |.:|.:.:......    ...:.||
  Rat   274 LKHQNSIIKHIRRSNRVYDSDDHSSHRTLIESFSRTNLLIPRRDKRHSGTSSMS----GHTAVPE 334

Human   400 KMSQEPEINKDCDREVEEEIKKHGSNPVGLPENLTNGASAG 440
            :.::.|.:.    ..|:|:            :|..||.:.|
  Rat   335 RSNEIPNLR----ATVKED------------DNPENGPNEG 359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POTEDNP_778146.2 Ank_4 143..193 CDD:290365 18/49 (37%)
ANK 167..292 CDD:238125 64/124 (52%)
ANK 1 172..201 12/28 (43%)
ANK repeat 174..203 CDD:293786 13/28 (46%)
Ank_2 177..269 CDD:289560 49/91 (54%)
ANK repeat 205..236 CDD:293786 18/30 (60%)
ANK 2 205..234 16/28 (57%)
ANK 233..357 CDD:238125 54/123 (44%)
ANK repeat 238..269 CDD:293786 17/30 (57%)
ANK 3 238..267 16/28 (57%)
Ank_2 243..335 CDD:289560 41/91 (45%)
ANK repeat 271..302 CDD:293786 12/30 (40%)
ANK 4 271..300 10/28 (36%)
ANK repeat 304..335 CDD:293786 13/30 (43%)
ANK 5 304..333 13/28 (46%)
ANK 6 337..366 7/47 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..502 13/75 (17%)
SH3_and_anchor <440..556 CDD:275056 1/1 (100%)
PotedXP_001079298.3 Ank_4 60..109 CDD:290365 18/48 (38%)
ANK repeat 60..87 CDD:293786 6/26 (23%)
ANK 84..209 CDD:238125 64/124 (52%)
ANK repeat 89..120 CDD:293786 13/30 (43%)
Ank_2 94..185 CDD:289560 49/90 (54%)
ANK repeat 125..153 CDD:293786 17/27 (63%)
ANK 150..274 CDD:238125 54/123 (44%)
ANK repeat 155..186 CDD:293786 17/30 (57%)
Ank_2 160..252 CDD:289560 41/91 (45%)
ANK repeat 188..219 CDD:293786 12/30 (40%)
ANK repeat 221..252 CDD:293786 13/30 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
HGNC 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D24863at7742
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24118
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.020

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