DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment POTED and act-2

DIOPT Version :9

Sequence 1:NP_778146.2 Gene:POTED / 317754 HGNCID:23822 Length:584 Species:Homo sapiens
Sequence 2:NP_001370033.1 Gene:act-2 / 179534 WormBaseID:WBGene00000064 Length:376 Species:Caenorhabditis elegans


Alignment Length:245 Identity:50/245 - (20%)
Similarity:99/245 - (40%) Gaps:48/245 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   215 QCQEDECVLML---LEHGADRNIPDEYGNTALHYAIYNEDKLMAK--ALLLYGADIESK-NKCGL 273
            :.|....:|.|   :|||...|..|.  ....|:..|||.::..:  .:||..|.:..| |:..:
 Worm    58 EAQSKRGILTLKYPIEHGIVTNWDDM--EKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKM 120

Human   274 TPLLL------GVHEQKQQVVKFLIKKKANLNVLDRYGRTALILAVCCGSASIVNLLLEQNVDVS 332
            |.::.      .::...|.|:......:....|||........:.:..|.| :.:.:|  .:|::
 Worm   121 TQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHTVPIYEGYA-LPHAIL--RLDLA 182

Human   333 SQDLSGQ-----TAREYAVSSHHHVICELLSDYKEK---------QMLKISSENSNPEQDLKLTS 383
            .:||:..     |.|.|:.::...  .|::.|.|||         |.:..::.:|:.|:..:|..
 Worm   183 GRDLTDYLMKILTERGYSFTTTAE--REIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPD 245

Human   384 EE----ESQRLKVSEN-SQPEKMSQEP---------EINKDCDREVEEEI 419
            .:    .::|.:..|. .||..:..|.         .|.| ||.::.:::
 Worm   246 GQVITVGNERFRCPEALFQPSFLGMESAGIHETSYNSIMK-CDIDIRKDL 294

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POTEDNP_778146.2 Ank_4 143..193 CDD:290365
ANK 167..292 CDD:238125 20/88 (23%)
ANK 1 172..201
ANK repeat 174..203 CDD:293786
Ank_2 177..269 CDD:289560 16/59 (27%)
ANK repeat 205..236 CDD:293786 7/23 (30%)
ANK 2 205..234 6/21 (29%)
ANK 233..357 CDD:238125 27/137 (20%)
ANK repeat 238..269 CDD:293786 8/33 (24%)
ANK 3 238..267 7/30 (23%)
Ank_2 243..335 CDD:289560 19/100 (19%)
ANK repeat 271..302 CDD:293786 4/36 (11%)
ANK 4 271..300 3/34 (9%)
ANK repeat 304..335 CDD:293786 4/30 (13%)
ANK 5 304..333 4/28 (14%)
ANK 6 337..366 9/42 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..502 12/65 (18%)
SH3_and_anchor <440..556 CDD:275056
act-2NP_001370033.1 PTZ00281 1..376 CDD:173506 50/245 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100127
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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