Protein Alignment Miga and MIGA2

DIOPT Version :9

• Sequence 1: NP_001162702.1
• Gene: Miga / 31775
• FlyBaseID: FBgn0030037
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_116198.3
• Gene: MIGA2 / 84895
• HGNCID: 23621
• Length: 657
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 189/559 - (33%)
• Similarity: 289/559 - (51%)
• Gaps: 99/559 - (17%)

  Fly    19 RVSTTTKVVLFSLTAGVALMSVLSRFLRRRK-----------------PPRPPRRARK------- 59
            |::...:.|||:...|...:::.:..|:||:                 .|.|...|||
Human   103 RLTPGLRKVLFATALGTVALALAAHQLKRRRRRKKQVGPEMGGEQLGTVPLPILLARKVPSVKKG 167

  Fly    60 YTGRRNRNSMRSPNDLIS-IAGSKASARSGS--PVGSTLAYSDRLSMASGSIGVGVLGVQNA-GP 120
            |:.||.::.....||.:| |:..:.|..|||  .|.|.:|.:.....|:.|      |:.:| |.
Human   168 YSSRRVQSPSSKSNDTLSGISSIEPSKHSGSSHSVASMMAVNSSSPTAACS------GLWDARGM 226

  Fly   121 GSSVVT-QLTAQQLGMMGMEALDTVINFWEDALA------AHYSP---GGL--------PALLTT 167
            ..|:.| ...|:.|.|.|||..:..:..||.||:      :..:|   .||        |.....
Human   227 EESLTTSDGNAESLYMQGMELFEEALQKWEQALSVGQRGDSGSTPMPRDGLRNPETASEPLSEPE 291

  Fly   168 AEDSEFCREIQNLLEMAYTLQEQ--------SELLFLDQRSVLFREEHSIDEAEEEAGEADDDRR 224
            ::..||..::::||..||.|||:        |.||.|::..:|...|
Human   292 SQRKEFAEKLESLLHRAYHLQEEFGSTFPADSMLLDLERTLMLPLTE------------------ 338

  Fly   225 SRKSGSVLSRAGSDPNFDSAESFASALDQVADLREFDGFIETSYEEYPL--------FQSALKHH 281
                ||:..||..:.:..|.:||.||.:....|:..|         ||:        ::.||:..
Human   339 ----GSLRLRADDEDSLTSEDSFFSATELFESLQTGD---------YPIPLSRPAAAYEEALQLV 390

  Fly   282 DEYTVPCRTIRAELMHCSTDTEYLAKLHCVRLAFQFLFKDPAVGQWICDAGRQILTDLLCLGDKD 346
            .|..|||||:|.||:.|.:|.::||||||||.||:.|.:|.:...:....|||::|.|:...:|.
Human   391 KEGRVPCRTLRTELLGCYSDQDFLAKLHCVRQAFEGLLEDKSNQLFFGKVGRQMVTGLMTKAEKS 455

  Fly   347 TKEFLVGYEDMVNYLHDSNNWPCIQMELEQRNVKAMTFYDICLDFIILDSFKDLDAPPASVTAVV 411
            .|.||..||:|::|......|...::|||.|.|..|:|:||.||||::|:|:||:.|||||.||:
Human   456 PKGFLESYEEMLSYALRPETWATTRLELEGRGVVCMSFFDIVLDFILMDAFEDLENPPASVLAVL 520

  Fly   412 QNRWLSNGFKETALTTAVWSVLKAKKRMLKFPNGFMSHFYVISEQISPLMAWGFFGPNENLRDIC 476
            :|||||:.||||||.||.|||||||:|:|..|:||:||||.:||.:||::|:||.||...|.::|
Human   521 RNRWLSDSFKETALATACWSVLKAKRRLLMVPDGFISHFYSVSEHVSPVLAFGFLGPKPQLAEVC 585

  Fly   477 HYFREELLAFLGDIFSFQKSRFTTIEEFSQDVLQHMQTR 515
            .:|:.:::.:|.|:|.....|:|::...:.|:||..:.|
Human   586 AFFKHQIVQYLRDMFDLDNVRYTSLPALADDILQLSRRR 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Miga	NP_001162702.1	DUF2217	13..523	CDD:287267	189/559 (34%)
MIGA2	NP_116198.3	DUF2217	95..632	CDD:287267	189/559 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147935
Domainoid	1	1.000	277	1.000	Domainoid score	I1735
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13125
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2943
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172440at33208
OrthoFinder	1	1.000	-	-		FOG0003203
OrthoInspector	1	1.000	-	-		otm42260
orthoMCL	1	0.900	-	-		OOG6_107527
Panther	1	1.100	-	-	LDO	PTHR21508
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3839
SonicParanoid	1	1.000	-	-		X2608
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.930