DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Miga and miga1

DIOPT Version :9

Sequence 1:	NP_001162702.1	Gene:	Miga / 31775	FlyBaseID:	FBgn0030037	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001006090.1	Gene:	miga1 / 450070	ZFINID:	ZDB-GENE-041010-193	Length:	595	Species:	Danio rerio

Alignment Length:	561	Identity:	184/561 - (32%)
Similarity:	285/561 - (50%)	Gaps:	91/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SLLPFRVSTTTKVVLFSLTA-GVALMSVLSRFLRRRKPPRPPRRARKYTGRRNRNS--------- 68
            ||....:||.|| .||:.|| |...:.:::|..||||            |||..||
Zfish    30 SLPQVSLSTGTK-KLFAATAFGAVSLIIIARRFRRRK------------GRRKANSPVEQETFEF 81

  Fly    69 ------------------MRSPNDLISIAGSKASARSGSPVGSTLAYSDRLSMASGSIGVGVLGV 115
                              ..:|.....::|:..:..||| :.|.::...|.|.:|.:...|....
Zfish    82 LTTIHLSKESDSQSVPQNSENPYTCNVVSGALYNKLSGS-LPSLVSVRSRHSSSSSTCANGSNCW 145

  Fly   116 QNAGPGSSVVTQL-----TAQQLGMMGMEALDTVINFWEDAL------------AAHYSPGGLPA 163
            :.||..:.|...|     |.:.|.:||||..:..:..||.||            ......|...|
Zfish   146 EEAGDAADVCNLLSLPVATPENLYLMGMELFEEALRRWEQALTFRSRQAEDEGSCVSVKLGAGDA 210

  Fly   164 LLTTAEDS-------EFCREIQNLLEMAYTLQEQSE--LLFLD----QRSVLFREEHSIDEAEEE 215
            :   ||:|       :|.:::::||:.||.|||:.|  |...|    ..:||..::|......||
Zfish   211 I---AEESMEDIISADFIQKLESLLQRAYRLQEEFEGSLGVTDPTTHPTNVLLADKHMDLSVREE 272

  Fly   216 AGEADDDRRSRKSGSVLSRAGSDPNFDSAESFASALDQVADLREF-DGFIETSYEEYPLFQSALK 279
            .    :|...|.|.|:.          |.:||.||. ::::.||. .|....|...:|.::.||:
Zfish   273 L----EDTCLRDSISIA----------STDSFVSAA-ELSEHREMRSGHALGSLSPHPFYEDALQ 322

  Fly   280 HHDEYTVPCRTIRAELMHCSTDTEYLAKLHCVRLAFQFLFKDPAVGQWICDAGRQILTDLLCLGD 344
            ..:|..:.||.:|.|::.|..|.::||||||||.|.|.:..:.|...::.|.|::||:.::....
Zfish   323 MAEEGKISCRVLRTEMLECLGDADFLAKLHCVRQACQVILCERATRAFLADTGKRILSAIIAKAR 387

  Fly   345 KDTKEFLVGYEDMVNYLHDSNNWPCIQMELEQRNVKAMTFYDICLDFIILDSFKDLDAPPASVTA 409
            |..|.|...:|:|:::|..:::|...:.||..|.||.|.|||:.||||::|||:||:.||.|:..
Zfish   388 KSPKRFEEVFEEMISFLEHTDHWENTENELSSRGVKHMNFYDVVLDFILMDSFEDLENPPLSIQT 452

  Fly   410 VVQNRWLSNGFKETALTTAVWSVLKAKKRMLKFPNGFMSHFYVISEQISPLMAWGFFGPNENLRD 474
            ||.||||||.|||||:.::.|||||.|::.:|..:||::|||.:.|.|||::||||.||...|:|
Zfish   453 VVNNRWLSNSFKETAVASSCWSVLKQKRQHMKVQDGFIAHFYAVCEHISPVLAWGFLGPKCTLQD 517

  Fly   475 ICHYFREELLAFLGDIFSFQKSRFTTIEEFSQDVLQHMQTR 515
            .|.:|:|::|.||.|||...|.|:.::|..::|:|..:..|
Zfish   518 FCCFFKEQVLFFLKDIFDLDKVRYFSLETLAEDILHLLHRR 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Miga	NP_001162702.1	DUF2217	13..523	CDD:287267	184/561 (33%)
miga1	NP_001006090.1	DUF2217	27..566	CDD:287267	184/561 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581829
Domainoid	1	1.000	268	1.000	Domainoid score	I1818
eggNOG	1	0.900	-	-		E1_KOG3831
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	268	1.000	Inparanoid score	I3004
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172440at33208
OrthoFinder	1	1.000	-	-		FOG0003203
OrthoInspector	1	1.000	-	-		otm25230
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21508
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3839
SonicParanoid	1	1.000	-	-		X2608
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.890