DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Miga and Miga1

DIOPT Version :9

Sequence 1:	NP_001162702.1	Gene:	Miga / 31775	FlyBaseID:	FBgn0030037	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_038959810.1	Gene:	Miga1 / 362058	RGDID:	1559958	Length:	611	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	177/579 - (30%)
Similarity:	287/579 - (49%)	Gaps:	96/579 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MPASWSSGGSLLPFRVSTTTKVVLFSLTAGVALMSVLSRFLRRR-------KPPRP-------PR 55
            :|.||....|.:.| .....|:.:.:..:.|:::.:...|.|||       .|..|       .|
  Rat    23 LPVSWYYSLSQIKF-PPAAKKLFMVTAVSAVSVIFLAHHFKRRRGKQKGKVLPWEPEHLLLEHTR 86

  Fly    56 RARKYTGRRNRNSMRSPNDLISIAGSKASARSGSPVGSTLAYSDRLSMASGSIG--VGVLGVQNA 118
            ||....|....:|.::....:|....|.|.....|.|..|:   |.|.::.|:|  ..|....:.
  Rat    87 RAASDKGSSCSSSRQNLTLSLSSTKDKGSQSCNYPNGGLLS---RYSGSAQSLGSVQSVNSCHSC 148

  Fly   119 GPGSS--------------VVTQLTAQQLGMMGMEALDTVINFWEDAL-------------AAHY 156
            ..|:|              .:...|.:.|.:||||..:..::.||.||             :...
  Rat   149 ACGNSNSWDKADDDDVRLVNIPVTTPENLYLMGMELFEEALHRWEQALTFRSRQAEDEACSSVKL 213

  Fly   157 SPGGLPA-----LLTTAED-------SEFCREIQNLLEMAYTLQEQSELLF-----------LDQ 198
            ..|...|     :.|:||:       :||..:::.||:.||.|||:.|...           .|:
  Rat   214 GAGDAIAEESVDVRTSAEEQASDIISTEFIHKLEALLQRAYRLQEEFEAALGGSDPDSLANDTDK 278

  Fly   199 RSVLFREEHSIDEAEEEAGEADDDRRSRKSGSVLSRAGSDPNFDSAESFASALDQVADLREFDGF 263
            .:.|     |:.|..:|.|..|                 ..|.|||:.|||| .::|:.||....
  Rat   279 DTDL-----SVRETVDEFGLPD-----------------TANIDSADLFASA-TELAEHREAQQA 320

  Fly   264 IE-TSYEEYPLFQSALKHHDEYTVPCRTIRAELMHCSTDTEYLAKLHCVRLAFQFLFKDPAVGQW 327
            :. .|:...|.::.|:...:|..:..|.:|.|::.|..|:::||||||:|.|||.:..:.....:
  Rat   321 LSLESFCRCPFYEEAMHLVEEGKIHSRVLRTEMLECLGDSDFLAKLHCIRQAFQLILAEADNRSF 385

  Fly   328 ICDAGRQILTDLLCLGDKDTKEFLVGYEDMVNYLHDSNNWPCIQMELEQRNVKAMTFYDICLDFI 392
            :.::||:||:.|:....|:.|:|...:::|:.:|..:::|...:|||..|.||.:.|||:.||||
  Rat   386 LAESGRKILSALIVKARKNPKKFQDVFDEMIYFLEQTDHWDSTEMELAARGVKNLNFYDVVLDFI 450

  Fly   393 ILDSFKDLDAPPASVTAVVQNRWLSNGFKETALTTAVWSVLKAKKRMLK-FPNGFMSHFYVISEQ 456
            ::|||:||:.||.|:.:||.|.|||..|||||:.::.|||||.|::.:| ..:||.:|||.|.|.
  Rat   451 LMDSFEDLENPPTSIQSVVTNHWLSASFKETAVASSCWSVLKQKRQQMKQISDGFFAHFYAICEH 515

  Fly   457 ISPLMAWGFFGPNENLRDICHYFREELLAFLGDIFSFQKSRFTTIEEFSQDVLQHMQTR 515
            |||::||||.||..:|.|:|.:|:.::|.||.|||.|:|.|:::|:..::| |.|:..|
  Rat   516 ISPVLAWGFLGPRNSLYDLCCFFKNQVLFFLKDIFDFEKVRYSSIDTLAED-LTHLLIR 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Miga	NP_001162702.1	DUF2217	13..523	CDD:287267	174/571 (30%)
Miga1	XP_038959810.1	Miga	27..582	CDD:402055	175/575 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341804
Domainoid	1	1.000	270	1.000	Domainoid score	I1754
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I2929
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172440at33208
OrthoFinder	1	1.000	-	-		FOG0003203
OrthoInspector	1	1.000	-	-		otm46414
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21508
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2608
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.000