Protein Alignment Miga and Miga1

DIOPT Version :9

• Sequence 1: NP_001162702.1
• Gene: Miga / 31775
• FlyBaseID: FBgn0030037
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_777357.2
• Gene: Miga1 / 215708
• MGIID: 1924567
• Length: 600
• Species: Mus musculus
• Alignment Length: 565
• Identity: 180/565 - (31%)
• Similarity: 287/565 - (50%)
• Gaps: 79/565 - (13%)

  Fly     5 MPASWSSGGSLLPFRVSTTTKVVLFSLTA--GVALMSVLSRFLRRR-------KPPRP------- 53
            :|.||..  ||...:.|...| .||.:||  .|:::.:...|.|||       .|..|
Mouse    23 LPVSWYY--SLSQIKFSPVAK-KLFMVTAVSAVSVIFLAHHFKRRRGKQKGKVLPWEPEHLLLEH 84

  Fly    54 PRRARKYTGRRNRNSMRSPNDLISIAGSKASARSGSPVGSTLAYSDRLSMASGSIG--VGVLGVQ 116
            .|||....|....:|.::....:|....|.|.....|.|..|:   |.|.::.|:|  ..|....
Mouse    85 TRRAASEKGSSCSSSRQNLTLSLSSTKEKGSQCCNYPNGGLLS---RYSGSAQSLGSVQSVNSCH 146

  Fly   117 NAGPGSS--------------VVTQLTAQQLGMMGMEALDTVINFWEDAL-----------AAHY 156
            :...|:|              .:...|.:.|.:||||..:..:..||.||           .:..
Mouse   147 SCACGNSNSWDKADDDDIRLVNIPVTTPENLYLMGMELFEEALRRWEQALTFRSRQAEDEACSSV 211

  Fly   157 SPGGLPALLTTAED----SEFCREIQNLLEMAYTLQEQSELLF--LDQRSVLFREEHSID----E 211
            ..|...|:...:.|    |||..:::.||:.||.|||:.|...  .|..|:....:...|    |
Mouse   212 KLGAGDAIAEESVDDIISSEFIHKLEALLQRAYRLQEEFEATLGGSDPNSIANDTDKDTDMSLRE 276

  Fly   212 AEEEAGEADDDRRSRKSGSVLSRAGSDPNFDSAESFASALDQVADLREF-DGFIETSYEEYPLFQ 275
            ..:|.|..|                 ..|.|||:.|||| .::|:.||. ..|...|:...|.::
Mouse   277 TMDELGLPD-----------------AMNMDSADLFASA-TELAEQREAQQTFSLESFCPCPFYE 323

  Fly   276 SALKHHDEYTVPCRTIRAELMHCSTDTEYLAKLHCVRLAFQFLFKDPAVGQWICDAGRQILTDLL 340
            .|:...:|..:..|.:|.|::.|..|:::||||||:|.|||.:..:.....::.::||:||:.|:
Mouse   324 EAMHLVEEGKIYSRVLRTEMLECLGDSDFLAKLHCIRQAFQLILAEADNRSFLAESGRKILSALI 388

  Fly   341 CLGDKDTKEFLVGYEDMVNYLHDSNNWPCIQMELEQRNVKAMTFYDICLDFIILDSFKDLDAPPA 405
            ....|:.|:|...:::|:|:|..:::|...::||..|.||.:.|||:.||||::|||:||:.||.
Mouse   389 VKARKNPKKFQDVFDEMINFLEQTDHWDSTELELAARGVKNLNFYDVVLDFILMDSFEDLENPPT 453

  Fly   406 SVTAVVQNRWLSNGFKETALTTAVWSVLKAKKRMLKFPNGFMSHFYVISEQISPLMAWGFFGPNE 470
            |:.:||.||||::.|||:|:.::.|||||.|::.:|..:||.:|||.|.|.:||::||||.||..
Mouse   454 SIQSVVNNRWLNSSFKESAVASSCWSVLKQKRQQMKISDGFFAHFYAICEHVSPVLAWGFLGPRN 518

  Fly   471 NLRDICHYFREELLAFLGDIFSFQKSRFTTIEEFSQDVLQHMQTR 515
            :|.|:|.:|:.::|.||.|||.|:|.|:::|:..::| |.|:..|
Mouse   519 SLYDLCCFFKNQVLFFLKDIFDFEKVRYSSIDTLAED-LTHLLIR 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Miga	NP_001162702.1	DUF2217	13..523	CDD:287267	177/557 (32%)
Miga1	NP_777357.2	DUF2217	27..571	CDD:287267	178/561 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838023
Domainoid	1	1.000	274	1.000	Domainoid score	I1760
eggNOG	1	0.900	-	-		E1_KOG3831
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2953
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172440at33208
OrthoFinder	1	1.000	-	-		FOG0003203
OrthoInspector	1	1.000	-	-		otm44314
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21508
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3839
SonicParanoid	1	1.000	-	-		X2608
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890