DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf2 and TBP

DIOPT Version :9

Sequence 1:	NP_001096905.1	Gene:	Trf2 / 31773	FlyBaseID:	FBgn0261793	Length:	1715	Species:	Drosophila melanogaster
Sequence 2:	NP_003185.1	Gene:	TBP / 6908	HGNCID:	11588	Length:	339	Species:	Homo sapiens

Alignment Length:	467	Identity:	108/467 - (23%)
Similarity:	186/467 - (39%)	Gaps:	183/467 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   995 LFEQQKQFVLEKLRQQKEQHRRQQNRVKRERKLRQKKEKQRLEYERFLKEYREDCKRQLRLQREH 1059
            |.|||:|       ||::|.::||.:.:::::.:|::::|:              ::|.:.|::.
Human    52 LEEQQRQ-------QQQQQQQQQQQQQQQQQQQQQQQQQQQ--------------QQQQQQQQQQ 95

  Fly  1060 YLIKIKQLEKASQRSLKGNRKHKLMQNDMVSIPVANLNGGLKAASSGSGVGVVTSGGVVSSAVLA 1124
            .:......:..||::.:|                                   |||
Human    96 AVAAAAVQQSTSQQATQG-----------------------------------TSG--------- 116

  Fly  1125 NAPRVYLTPSSTFMTNRQMAGVASTGRMSGQVVGGSSGTASTAGTVRYFSQFSKMQTAGGPSLQR 1189
            .||:::.:.:.|                          ||...||...:.......|...|:
Human   117 QAPQLFHSQTLT--------------------------TAPLPGTTPLYPSPMTPMTPITPA--- 152

  Fly  1190 KLANGDTIVLATGSKNMFLTSSENKANLPTVASNGNGLITAKMDLLEEEVMQSITVIDDDDEEKK 1254
                                         |.||..:|::..
Human   153 -----------------------------TPASESSGIVPQ------------------------ 164

  Fly  1255 EVAEDEEESSNNAKPIDLHQPIADNEHELDIVINNVVCSFSVGCHLKLREIALQGSNVEYR-REN 1318
                                            :.|:|.:.::||.|.|:.|||:..|.||. :..
Human   165 --------------------------------LQNIVSTVNLGCKLDLKTIALRARNAEYNPKRF 197

  Fly  1319 GMVTMKLRHPYTTASIWSSGRITCTGATSESMAKVAARRYARCLGKLGFPTRFLNFRIVNVLGTC 1383
            ..|.|::|.|.|||.|:|||::.||||.||..:::|||:|||.:.|||||.:||:|:|.|::|:|
Human   198 AAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSC 262

  Fly  1384 SMPWAIKIVNFSERHRENASYEPELHPGVTYKMRDPDPKATLKIFSTGSVTVTAASVN-HVESAI 1447
            .:.:.|::......|::.:||||||.||:.|:|  ..|:..|.||.:|.|.:|.|.|. .:..|.
Human   263 DVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRM--IKPRIVLLIFVSGKVVLTGAKVRAEIYEAF 325

  Fly  1448 QHIYPLVFDFRK 1459
            ::|||::..|||
Human   326 ENIYPILKGFRK 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf2	NP_001096905.1	GBP_C	<967..1068	CDD:303769	14/72 (19%)
		coiled coil	1037..1048	CDD:293879	0/10 (0%)
		coiled coil	1057..1068	CDD:293879	0/10 (0%)
		TLF	1283..1456	CDD:239953	72/174 (41%)
		PLN00062	1285..1459	CDD:177693	73/175 (42%)
TBP	NP_003185.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		polyglutamine repeat	58..95		10/57 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..159		10/89 (11%)
		PLN00062	162..338	CDD:177693	75/234 (32%)
		Repetitive region	165..241		35/75 (47%)
		Repetitive region	255..332		29/78 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1219067at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820