DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf2 and Tbpl2

DIOPT Version :9

Sequence 1:	NP_001096905.1	Gene:	Trf2 / 31773	FlyBaseID:	FBgn0261793	Length:	1715	Species:	Drosophila melanogaster
Sequence 2:	NP_001092831.1	Gene:	Tbpl2 / 680050	RGDID:	1596837	Length:	344	Species:	Rattus norvegicus

Alignment Length:	302	Identity:	103/302 - (34%)
Similarity:	161/302 - (53%)	Gaps:	34/302 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1174 SQFSKMQTAGGPSLQRKLANGDTIVLATGSKNMFLTSSEN------KANLPTVASNGNGLITAKM 1232
            |.||.:..:..|. :....|.|..|  ||:|   :|:.|:      ::.|......|:||   .:
  Rat    60 SDFSSVDLSFLPD-ELTQENKDRTV--TGNK---VTNEESFRTQDWQSQLQLPDEQGSGL---NL 115

  Fly  1233 DLLEEEVMQSITVIDDDDEEKKEVAEDEEESSNNAKPIDL------HQPIADNEHELDIV--INN 1289
            :.......||.....|.|..:.    ..|..::||.|:.|      ..|:.:..   .||  :.|
  Rat   116 NSNSSPDTQSCLCSHDADSNQL----SSETPNSNALPVVLISSMTPMNPVTECS---GIVPQLQN 173

  Fly  1290 VVCSFSVGCHLKLREIALQGSNVEYR-RENGMVTMKLRHPYTTASIWSSGRITCTGATSESMAKV 1353
            ||.:.::.|.|.||:|||...|.||. :....|.|::|.|.|||.|:|||::.||||.||..:::
  Rat   174 VVSTANLACKLDLRKIALNAKNTEYNPKRFAAVIMRIREPRTTALIFSSGKVVCTGAKSEDESRL 238

  Fly  1354 AARRYARCLGKLGFPTRFLNFRIVNVLGTCSMPWAIKIVNFSERHRENASYEPELHPGVTYKMRD 1418
            |||:|||.:.|||||.||.||:|.|::.:|.:.:.|::...:..||:.:||||||.||:.|||
  Rat   239 AARKYARVVQKLGFPVRFFNFKIQNMVASCDVKFPIRLEILALTHRQFSSYEPELFPGLIYKM-- 301

  Fly  1419 PDPKATLKIFSTGSVTVTAASV-NHVESAIQHIYPLVFDFRK 1459
            ..|:..|.||::|.|.:|.|.. :.:..|.:::||::..|:|
  Rat   302 VKPQVVLLIFASGKVVLTGAKERSEIYEAFENMYPILESFKK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf2	NP_001096905.1	GBP_C	<967..1068	CDD:303769
		coiled coil	1037..1048	CDD:293879
		coiled coil	1057..1068	CDD:293879
		TLF	1283..1456	CDD:239953	75/176 (43%)
		PLN00062	1285..1459	CDD:177693	76/177 (43%)
Tbpl2	NP_001092831.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..143		17/76 (22%)
		PLN00062	168..344	CDD:177693	76/178 (43%)
		TBP_eukaryotes	168..341	CDD:239952	74/174 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1219067at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820