DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf2 and tbpl1

DIOPT Version :9

Sequence 1:	NP_001096905.1	Gene:	Trf2 / 31773	FlyBaseID:	FBgn0261793	Length:	1715	Species:	Drosophila melanogaster
Sequence 2:	NP_001004932.1	Gene:	tbpl1 / 448323	XenbaseID:	XB-GENE-488460	Length:	186	Species:	Xenopus tropicalis

Alignment Length:	183	Identity:	105/183 - (57%)
Similarity:	134/183 - (73%)	Gaps:	2/183 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly  1277 ADNEHELDIVINNVVCSFSVGCHLKLREIALQGSNVEYRRENGMVTMKLRHPYTTASIWSSGRIT 1341
            ||::..|||:|.||||.|...|||.||:|||:|.||.|:||.|.|.||||.|..||:|||||:|.
Frog     3 ADSDVALDIIITNVVCVFRTRCHLNLRKIALEGLNVIYKREVGKVLMKLRKPRITATIWSSGKII 67

  Fly  1342 CTGATSESMAKVAARRYARCLGKLGFPTRFLNFRIVNVLGTCSMPWAIKIVNFSERHRENASYEP 1406
            |||||||..|||.|||.||.|.||||..:|..|::||||..|:||:.|::..|::::|.:|||||
Frog    68 CTGATSEEEAKVGARRLARSLQKLGFQVKFTEFKVVNVLAVCTMPFEIRLAEFTKQNRPHASYEP 132

  Fly  1407 ELHPGVTYKMRDPDPKATLKIFSTGSVTVTAASVNHVESAIQHIYPLVFDFRK 1459
            ||||.|.|:::  ..:.||:||||||:|||...|..|.:||:.|||.||:.||
Frog   133 ELHPAVCYRIK--SLRTTLQIFSTGSITVTGPDVKSVATAIEQIYPFVFESRK 183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf2	NP_001096905.1	GBP_C	<967..1068	CDD:303769
		coiled coil	1037..1048	CDD:293879
		coiled coil	1057..1068	CDD:293879
		TLF	1283..1456	CDD:239953	100/172 (58%)
		PLN00062	1285..1459	CDD:177693	99/173 (57%)
tbpl1	NP_001004932.1	TLF	9..180	CDD:239953	100/172 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6683
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1219067at2759
OrthoFinder	1	1.000	-	-		FOG0005864
OrthoInspector	1	1.000	-	-		oto102559
Panther	1	1.100	-	-	LDO	PTHR10126
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5023
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.050