DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trf2 and tbpl2

DIOPT Version :9

Sequence 1:	NP_001096905.1	Gene:	Trf2 / 31773	FlyBaseID:	FBgn0261793	Length:	1715	Species:	Drosophila melanogaster
Sequence 2:	XP_005169867.1	Gene:	tbpl2 / 407713	ZFINID:	ZDB-GENE-040520-3	Length:	313	Species:	Danio rerio

Alignment Length:	321	Identity:	107/321 - (33%)
Similarity:	169/321 - (52%)	Gaps:	51/321 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1172 YFSQFSKMQTAGGPSLQRKLANGDTIVLATGSKNMFLTSSENKANLPTVASNGNGLITAKMDL-- 1234
            ||.     ||..|.|  ..:..||  :...||.:....||    .|.::||....| |..:||
Zfish    12 YFD-----QTIAGSS--DYIFEGD--LGLQGSTSQLQDSS----FLSSLASQEKDL-TEDLDLSF 62

  Fly  1235 LEEEVMQSITVIDDDDEEK------------KEVAEDEEESSNNAK-------------PIDLHQ 1274
            |.:|:.........:.|.|            ||..:.:.::||:|:             |:....
Zfish    63 LPDELSTQDEPSQVEKESKNEDSGIYTDCPQKESTQADIDTSNSAQNTSQFNLPMTPMTPMTPMT 127

  Fly  1275 PIADNEHELDIV--INNVVCSFSVGCHLKLREIALQGSNVEYR-RENGMVTMKLRHPYTTASIWS 1336
            |:|::.   .|:  :.|:|.:.::.|.|.|:.||||..|.||. :....|.|::|.|.|||.|:|
Zfish   128 PVAESS---GIIPQLQNIVSTVNLACPLDLKSIALQARNAEYNPKRFAAVIMRIREPRTTALIFS 189

  Fly  1337 SGRITCTGA-TSESMAKVAARRYARCLGKLGFPTRFLNFRIVNVLGTCSMPWAIKIVNFSERHRE 1400
            ||::.|||| :||..:::|||:|||.:.|||||.:||:|:|.|::|:|.:.:.|::......|::
Zfish   190 SGKMVCTGAKSSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVCFPIRLEGLVLTHQQ 254

  Fly  1401 NASYEPELHPGVTYKMRDPDPKATLKIFSTGSVTVTAASV-NHVESAIQHIYPLVFDFRKQ 1460
            .:||||||.||:.|:|  ..|:..|.||.:|.|.:|.|.. :.:..|.::|||::..||||
Zfish   255 FSSYEPELFPGLIYRM--VKPRIVLLIFVSGKVVLTGAKERSEIYEAFENIYPILKGFRKQ 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf2	NP_001096905.1	GBP_C	<967..1068	CDD:303769
		coiled coil	1037..1048	CDD:293879
		coiled coil	1057..1068	CDD:293879
		TLF	1283..1456	CDD:239953	72/177 (41%)
		PLN00062	1285..1459	CDD:177693	73/178 (41%)
tbpl2	XP_005169867.1	PLN00062	136..312	CDD:177693	72/177 (41%)
tbpl2	XP_005169867.1	TBP_eukaryotes	136..310	CDD:239952	71/175 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1219067at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820