Protein Alignment Trf2 and TBPL2

DIOPT Version :10

• Sequence 1: NP_001096905.1
• Gene: Trf2 / 31773
• FlyBaseID: FBgn0261793
• Length: 1715
• Species: Drosophila melanogaster
• Sequence 2: NP_950248.2
• Gene: TBPL2 / 387332
• HGNCID: 19841
• Length: 343
• Species: Homo sapiens
• Alignment Length: 320
• Identity: 93/320 - (29%)
• Similarity: 157/320 - (49%)
• Gaps: 78/320 - (24%)

  Fly  1205 NMFLTSSENKANLPTVASNGNGLI--------TAKMDLLEEEVMQSITVIDDDDEEKKEVAEDE- 1260
            :|::.::.|    |..|.|.|..:        :..:..|.:||.|       :::::..:::.|
Human    36 DMYILNASN----PDTAFNSNPEVKETSGDFSSVDLSFLPDEVTQ-------ENKDQPVISKHET 89

  Fly  1261 EESSNNAKP-------------IDLHQPIADNEH------ELDIV-------------------- 1286
            ||:|.:..|             :.|:.....|.|      :.|.|
Human    90 EENSESQSPQSRLPSPSEQDVGLGLNSSSLSNSHSQLHPGDTDSVQPSPEKPNSDSLSLASITPM 154

  Fly  1287 ---------------INNVVCSFSVGCHLKLREIALQGSNVEYR-RENGMVTMKLRHPYTTASIW 1335
                           :.|:|.:.::.|.|.|::|||...|.||. :....|.|::|.|.|||.|:
Human   155 TPMTPISECCGIVPQLQNIVSTVNLACKLDLKKIALHAKNAEYNPKRFAAVIMRIREPRTTALIF 219

  Fly  1336 SSGRITCTGATSESMAKVAARRYARCLGKLGFPTRFLNFRIVNVLGTCSMPWAIKIVNFSERHRE 1400
            |||::.||||.||..:::|||:|||.:.|||||.|||:|:|.|::|:|.:.:.|::......|::
Human   220 SSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPARFLDFKIQNMVGSCDVRFPIRLEGLVLTHQQ 284

  Fly  1401 NASYEPELHPGVTYKMRDPDPKATLKIFSTGSVTVTAASV-NHVESAIQHIYPLVFDFRK 1459
            .:||||||.||:.|:|  ..|:..|.||.:|.|.:|.|.. :.:..|.::|||::..|:|
Human   285 FSSYEPELFPGLIYRM--VKPRIVLLIFVSGKVVLTGAKERSEIYEAFENIYPILKGFKK 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trf2	NP_001096905.1	PHA03418	<644..732	CDD:177646
		DUF5401	<891..>1088	CDD:375164
		TLF	1283..1456	CDD:239953	73/209 (35%)
TBPL2	NP_950248.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..152		13/87 (15%)
		PLN00062	167..342	CDD:177693	72/176 (41%)