DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf2 and Tbp

DIOPT Version :9

Sequence 1:	NP_001096905.1	Gene:	Trf2 / 31773	FlyBaseID:	FBgn0261793	Length:	1715	Species:	Drosophila melanogaster
Sequence 2:	NP_038712.3	Gene:	Tbp / 21374	MGIID:	101838	Length:	316	Species:	Mus musculus

Alignment Length:	175	Identity:	75/175 - (42%)
Similarity:	116/175 - (66%)	Gaps:	4/175 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1287 INNVVCSFSVGCHLKLREIALQGSNVEYR-RENGMVTMKLRHPYTTASIWSSGRITCTGATSESM 1350
            :.|:|.:.::||.|.|:.|||:..|.||. :....|.|::|.|.|||.|:|||::.||||.||..
Mouse   142 LQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQ 206

  Fly  1351 AKVAARRYARCLGKLGFPTRFLNFRIVNVLGTCSMPWAIKIVNFSERHRENASYEPELHPGVTYK 1415
            :::|||:|||.:.|||||.:||:|:|.|::|:|.:.:.|::......|::.:||||||.||:.|:
Mouse   207 SRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYR 271

  Fly  1416 MRDPDPKATLKIFSTGSVTVTAASVN-HVESAIQHIYPLVFDFRK 1459
            |  ..|:..|.||.:|.|.:|.|.|. .:..|.::|||::..|||
Mouse   272 M--IKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRK 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf2	NP_001096905.1	GBP_C	<967..1068	CDD:303769
		coiled coil	1037..1048	CDD:293879
		coiled coil	1057..1068	CDD:293879
		TLF	1283..1456	CDD:239953	72/170 (42%)
		PLN00062	1285..1459	CDD:177693	73/173 (42%)
Tbp	NP_038712.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..135
		PLN00062	139..315	CDD:177693	75/175 (43%)
		TBP_eukaryotes	139..312	CDD:239952	72/171 (42%)
		Repetitive region	142..218		35/75 (47%)
		Repetitive region	232..309		29/78 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1219067at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820