Protein Alignment Trf2 and tlf-1

DIOPT Version :9

• Sequence 1: NP_001096905.1
• Gene: Trf2 / 31773
• FlyBaseID: FBgn0261793
• Length: 1715
• Species: Drosophila melanogaster
• Sequence 2: NP_001122474.1
• Gene: tlf-1 / 172676
• WormBaseID: WBGene00006577
• Length: 508
• Species: Caenorhabditis elegans
• Alignment Length: 581
• Identity: 131/581 - (22%)
• Similarity: 230/581 - (39%)
• Gaps: 197/581 - (33%)

  Fly   945 QEKLLQQE---KQLQQE-------KHLPQERQLQQD------------KVFLQLRQLQ------- 980
            |::::|..   :|:||.       :.:|..:.:|.:            .|.:|:|.:|
 Worm    53 QQRIVQLPPGVRQIQQNGVGPAYVRQVPGGQPMQVNFGHPGTIAGRNVAVGVQMRPVQGHNVQQG 117

  Fly   981 -QKKELEEQ-RERKRHLFEQQKQFVLEKLRQQKEQHRRQQNRVKRERKLRQKKEKQRLEYERFLK 1043
             |::::..| :::.|.:|..|.|...:::...:.|||:||          |.:::...:.:.|..
 Worm   118 YQRQQVANQIQQQNRAVFMAQNQQGQQQISYAQAQHRQQQ----------QNQQQHHQQPQHFNH 172

  Fly  1044 EYREDCKRQLRLQREHYLIKIKQLEKASQRSLKGNRKHKLMQNDMVSIPVANLNGGLKAASSGSG 1108
            ..:::   |:.:|..             |..:..|::|:::|
 Worm   173 PSQQN---QMIMQHR-------------QPQMHHNQQHQMVQ----------------------- 198

  Fly  1109 VGVVTSGGVVSSAVLANAPRVYLTPSSTFMTNRQMAGVASTGRMSGQVVGGSSGTASTAGTVRYF 1173
                              |:         ||..|||
 Worm   199 ------------------PQ---------MTRHQMA----------------------------- 207

  Fly  1174 SQFSKMQTAGGPSLQRKLANGDTIVLATGSKNMFLTSSENKANLPTVASNGNGLITAKMDLLEEE 1238
                 ...|..|..|                 :::....|.| :|                |.|.
 Worm   208 -----QHHAQQPHPQ-----------------IYVPRDMNLA-VP----------------LREP 233

  Fly  1239 VMQSITVIDDDDEEKKEVAEDEEESSNNAKPIDLHQPIADNEHELDIVINNVVCSFSVGCHLKLR 1303
            ..:.|.|       |.||.:...|.::.|.    .:|:.| :.::||.|.||||::::..|:.||
 Worm   234 SPEPIPV-------KIEVPDVPPEGTSAAN----EEPMPD-DGDIDIQIRNVVCNYTLPLHIDLR 286

  Fly  1304 EIALQGSNVEYRRENGMVTMKLRHPYTTASIWSSGRITCTGATSESMAKVAARRYA----RCLGK 1364
            ::|:...||.|.||.|::..:.|.|.....::|||::...|..||:..|.|||..|    |.:||
 Worm   287 KLAMNTHNVTYEREKGVMMKQKRSPGCYIKVYSSGKVYIVGCRSEADCKRAARSIARHVQRVMGK 351

  Fly  1365 LGFPTRFLNFRIVNVLGTCSMPWAIKIVNFSERHRENASYEPELHPGVTYKMRDPDPKATLKIFS 1429
            ........|:|:.|||.||.:|:.|||...:.::...::|||||..|:.:  |...|||||:|.:
 Worm   352 TKERVSIRNYRVNNVLATCRLPFGIKIEEVAAKYPSESTYEPELSVGLVW--RSVTPKATLRIHT 414

  Fly  1430 TGSVTVTAA-SVNHVESAIQHIYPLVFDFRKQRSAEELQHLRQKQRLQA---GGDPHELEK 1486
            |||:|||.| |...|...:..|||:|.:||....|:.....::|::.:|   .|.|.:.|:
 Worm   415 TGSITVTGAQSEADVLEVLSKIYPIVLEFRCLERAKGNVAAQKKRKRKAPVNRGPPIKRER 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trf2	NP_001096905.1	GBP_C	<967..1068	CDD:303769	20/121 (17%)
		coiled coil	1037..1048	CDD:293879	1/10 (10%)
		coiled coil	1057..1068	CDD:293879	0/10 (0%)
		TLF	1283..1456	CDD:239953	70/177 (40%)
		PLN00062	1285..1459	CDD:177693	70/178 (39%)
tlf-1	NP_001122474.1	Med15	<3..>218	CDD:312941	39/291 (13%)
		KLF1_2_4_N	<183..217	CDD:425360	12/130 (9%)
		TLF	266..442	CDD:239953	70/177 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160120
Domainoid	1	1.000	68	1.000	Domainoid score	I6394
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005864
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108142
Panther	1	1.100	-	-	LDO	PTHR10126
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840