DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-T and GPI16

DIOPT Version :9

Sequence 1:	NP_572475.1	Gene:	PIG-T / 31772	FlyBaseID:	FBgn0030035	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_012058.1	Gene:	GPI16 / 856595	SGDID:	S000001231	Length:	610	Species:	Saccharomyces cerevisiae

Alignment Length:	644	Identity:	160/644 - (24%)
Similarity:	259/644 - (40%)	Gaps:	174/644 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLLLLVAPNADANLGRDDERFH---EELVVRPLSGDHVNTYFQF----------TTRWHYGEKDN 58
            :||.:.|.:..:.:|.:|..::   |.||::||..:.:...|.|          .:...|   |.
Yeast    13 LLLGVFAEDTVSQIGINDSLWYPYDEALVLKPLPNNDLLLSFAFQLQSEPFDPAVSSMSY---DA 74

  Fly    59 LYHTQLTPRVIAELLQQFAVKELHIGLTQGLWRYETWG---YPIVEA-TSGAEMWAWFSGANLTN 119
            ..|....||.|..||:..|.::.|:..|:|.|...:||   :...|| .||.|:|:....  :..
Yeast    75 YEHYTTFPRAIPPLLESTATRQFHLRFTRGFWDALSWGQLPHAGKEAGASGVELWSQVQA--MDQ 137

  Fly   120 RDVDRQWKELANVFSGVLCASLNFVDNTNSIAPRHL----IRPQFMPANGQRFVRYATLPREIVC 180
            ......||:|:|..||:.|:||||:|.:.:..||..    |......:..:.::..|:||.|.:|
Yeast   138 EQAFHNWKKLSNSLSGLFCSSLNFIDESRTTFPRRSYASDIGAPLFNSTEKLYLMRASLPNEPIC 202

  Fly   181 TENLTPWKKLLPCGSASGFASLLNSGHVHNTKYHSLGLKVRVLCEDHDEDNCIVELTQTANLV-- 243
            ||||||:.||||....||..|||:...:.::.::|:.|.:..:|.:.::..|..|:.....:|
Yeast   203 TENLTPFIKLLPTRGKSGLTSLLDGHKLFDSLWNSISLDIATICSEDEDALCHYEMDARIEMVTH 267

  Fly   244 ----------------------------YD----LRLFELSNNDFSLRRLFGMGLNG-------- 268
                                        :|    ..|.|.|...|.|.:||...:|.
Yeast   268 VPSALARGERPIPKPLDGNTLRCDTDKPFDSYQCFPLPEPSQTHFKLSQLFARPINNGNLFANRP 332

  Fly   269 --YCELAESS--------------------KIYVQRNELGERYQLVPEPVHEVKTTRGGHSVVYS 311
              .|...:.|                    .:...:||.|..|..:.|.....|.|
Yeast   333 TRICAEVDRSTWTAFLSVDDTIFSTHDNCFDLSNDQNEGGSGYDFILESTDTTKVT--------- 388

  Fly   312 VYDMHEQFKEAGERLFNVAWLAPKSANRRRNLAKPSLP-PVTVHRYLLGHGQERGRIVTEVTNSH 375
                                              |.:| |:.|.|.|.|:||:||.:.....|.:
Yeast   389 ----------------------------------PIVPVPIHVSRSLTGNGQDRGGMRIVFHNDN 419

  Fly   376 YDALPIMLQEVIPWYVHAYLHTLSI--RRKPQR------VNEYGGQRLTFKLLHYTPGKQRELPS 432
            ...:.::..|.:||::..||.:|.|  ...||.      :::|           |.....|:.|.
Yeast   420 DTPVKLIYFESLPWFMRVYLSSLQITSTTSPQLQENDIILDKY-----------YLQAADRKRPG 473

  Fly   433 HLEIGFMLPGQTSALISIDVDYLLLKWLEYPPDANHGHYIGSAIVSSQLPMGRNYTALPPEGHLF 497
            |||...::|..|..:::...|..||::.|||||||||..|.:|:::        ..:|.....|:
Yeast   474 HLEFTMLIPANTDIVMTYQFDKALLQFAEYPPDANHGFEIDAAVIT--------VLSLESSSSLY 530

  Fly   498 EHSFNATRPSYVLSLHTEALIVSLPTPDFSMPYNVICLACTVVALAFGPIHSVATKMII 556
            |             :.|..|::||.|||||||||||.|..|::.|.||.::::..|.::
Yeast   531 E-------------MRTSTLLLSLSTPDFSMPYNVIILTSTIMGLIFGMLYNLMVKRMV 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-T	NP_572475.1	Gpi16	27..553	CDD:282031	154/619 (25%)
GPI16	NP_012058.1	Gpi16	35..589	CDD:397988	155/622 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345877
Domainoid	1	1.000	218	1.000	Domainoid score	I470
eggNOG	1	0.900	-	-		E1_KOG2407
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6134
Inparanoid	1	1.050	220	1.000	Inparanoid score	I770
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55326
OrthoFinder	1	1.000	-	-		FOG0003522
OrthoInspector	1	1.000	-	-		oto99238
orthoMCL	1	0.900	-	-		OOG6_103068
Panther	1	1.100	-	-	LDO	PTHR12959
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R513
SonicParanoid	1	1.000	-	-		X2402
TreeFam	1	0.960	-	-
	15	14.790