DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-T and PIGT

DIOPT Version :9

Sequence 1:	NP_572475.1	Gene:	PIG-T / 31772	FlyBaseID:	FBgn0030035	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_057021.2	Gene:	PIGT / 51604	HGNCID:	14938	Length:	578	Species:	Homo sapiens

Alignment Length:	594	Identity:	225/594 - (37%)
Similarity:	332/594 - (55%)	Gaps:	42/594 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PVAFVLLLLVAPN--ADANLGRDDERFHEELVVRPLSGDHVNTYFQFTTRWHYG-EKDNLYHTQL 64
            |:|.::|||:.|.  ..|...||..|  ||||:.||....|...|||.|||... :::.:.|.:|
Human     6 PLALLVLLLLGPGGWCLAEPPRDSLR--EELVITPLPSGDVAATFQFRTRWDSELQREGVSHYRL 68

  Fly    65 TPRVIAELLQQFAVKELHIGLTQGLWRYETWGYPIVEATSGAEMWAWFSGANLTNRDVDRQWKEL 129
            .|:.:.:|:.:::::|||:..|||.||...||.|.::|.||||:|.||..   |..|||:.||||
Human    69 FPKALGQLISKYSLRELHLSFTQGFWRTRYWGPPFLQAPSGAELWVWFQD---TVTDVDKSWKEL 130

  Fly   130 ANVFSGVLCASLNFVDNTNSIAPRHLIRPQFMPAN--GQRFVRYATLPREIVCTENLTPWKKLLP 192
            :||.||:.||||||:|:||::.|....:|..: ||  ...|:|||.||||:||||||||||||||
Human   131 SNVLSGIFCASLNFIDSTNTVTPTASFKPLGL-ANDTDHYFLRYAVLPREVVCTENLTPWKKLLP 194

  Fly   193 CGSASGFASLLNSGHVHNTKYHSLGLKVRVLCEDHDEDNCIVELTQTANLVYDLRLFELSNNDFS 257
            |.|.:|.:.||.:..:.:|.|||..:.:|.:|.:....:...||.||.::|:|..:......|:|
Human   195 CSSKAGLSVLLKADRLFHTSYHSQAVHIRPVCRNARCTSISWELRQTLSVVFDAFITGQGKKDWS 259

  Fly   258 LRRLFGMGLNGYCELAESSKIYVQ---RNELGERYQLVPEPVHEVKTTRGGHSVVYSVYDMHEQF 319
            |.|:|...|...|.||..|::||.   .|:..|..::.|.|....:....|....|::||:.:..
Human   260 LFRMFSRTLTEPCPLASESRVYVDITTYNQDNETLEVHPPPTTTYQDVILGTRKTYAIYDLLDTA 324

  Fly   320 KEAGERLFNV--AWLAPKSANRRRNLAKPSLPPVTVHRYLLGHGQERGRIVTEVTNSH-YDALPI 381
            .....|..|:  .|..|.     .|.| |.:|.:...||:.|:|.::|.:.|.:.|:| |.|.|:
Human   325 MINNSRNLNIQLKWKRPP-----ENEA-PPVPFLHAQRYVSGYGLQKGELSTLLYNTHPYRAFPV 383

  Fly   382 MLQEVIPWYVHAYLHTLSIRRKPQRVNEYGGQRLTFKLLHYTPGKQRELPSHLEIGFMLPGQTSA 446
            :|.:.:|||:..|:|||:|..|        |:......:||.|.:.|..|..||:...||..:..
Human   384 LLLDTVPWYLRLYVHTLTITSK--------GKENKPSYIHYQPAQDRLQPHLLEMLIQLPANSVT 440

  Fly   447 LISIDVDYLLLKWLEYPPDANHGHYIGSAIVSSQLPMGRNYTALPP----EGHLFEHSFNATRPS 507
            .:||..:..||||.||.||.|||.|:..:::|:.:|   :..|..|    |..||...|..:..|
Human   441 KVSIQFERALLKWTEYTPDPNHGFYVSPSVLSALVP---SMVAAKPVDWEESPLFNSLFPVSDGS 502

  Fly   508 -YVLSLHTEALIVSLPTPDFSMPYNVICLACTVVALAFGPIHSVATKMIIVGRQTSAPKNFVKKI 571
             |.:.|:||.|:|:|||||||||||||||.|||||:.:|..:::.|:...:....:.  ...|::
Human   503 NYFVRLYTEPLLVNLPTPDFSMPYNVICLTCTVVAVCYGSFYNLLTRTFHIEEPRTG--GLAKRL 565

  Fly   572 FNQLFRRGK 580
            .| |.||.:
Human   566 AN-LIRRAR 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-T	NP_572475.1	Gpi16	27..553	CDD:282031	209/539 (39%)
PIGT	NP_057021.2	Gpi16	32..565	CDD:309297	211/555 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158340
Domainoid	1	1.000	379	1.000	Domainoid score	I856
eggNOG	1	0.900	-	-		E1_KOG2407
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6134
Inparanoid	1	1.050	387	1.000	Inparanoid score	I2032
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55326
OrthoDB	1	1.010	-	-		D143619at33208
OrthoFinder	1	1.000	-	-		FOG0003522
OrthoInspector	1	1.000	-	-		oto89056
orthoMCL	1	0.900	-	-		OOG6_103068
Panther	1	1.100	-	-	LDO	PTHR12959
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R513
SonicParanoid	1	1.000	-	-		X2402
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800