Protein Alignment KLHL10 and kel

DIOPT Version :10

• Sequence 1: NP_689680.2
• Gene: KLHL10 / 317719
• HGNCID: 18829
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_476589.4
• Gene: kel / 35084
• FlyBaseID: FBgn0001301
• Length: 1477
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 206/600 - (34%)
• Similarity: 312/600 - (52%)
• Gaps: 25/600 - (4%)

Human    13 HQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEK 77
            ::.|..|...||     ||:|.:.:||||::..:..|..||:.:|.|||.||.|:|||...:.:.
  Fly   136 NEQHTARSFDAM-----NEMRKQKQLCDVILVADDVEIHAHRMVLASCSPYFYAMFTSFEESRQA 195

Human    78 KVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCI 142
            :: .:..:....::|:|:|.||.||.:..|||:.||.||:...:..:...||:||:::|...||:
  Fly   196 RI-TLQSVDARALELLIDYVYTATVEVNEDNVQVLLTAANLLQLTDVRDACCDFLQTQLDASNCL 259

Human   143 GICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAI 207
            ||.:|.|.:.|.||...|..:|..:|.|:::.. |||.||..::..:|..|.::|..|:.|:|.:
  Fly   260 GIREFADIHACVELLNYAETYIEQHFNEVIQFD-EFLNLSHEQVISLIGNDRISVPNEERVYECV 323

Human   208 LKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMN 272
            :.|:.:|...|:|..|:|:..|||..:..||....|.....::.:..||.:||.||  .|.|
  Fly   324 IAWLRYDVPMREQFTSLLMEHVRLPFLSKEYITQRVDKEILLEGNIVCKNLIIEAL--TYHL--- 383

Human   273 GPSNSDFTNPLTRPRLPYA---ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGA 334
              ..::..:..|.||.|..   ||..||| .......::|.||.|.::|.. ..|..:.|...|.
  Fly   384 --LPTETKSARTVPRKPVGMPKILLVIGG-QAPKAIRSVEWYDLREEKWYQ-AAEMPNRRCRSGL 444

Human   335 AYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVR 399
            :.|...||.:|||:......:|..:||....|...:.|.:||..:.|.||...|||:|||||...
  Fly   445 SVLGDKVYAVGGFNGSLRVRTVDVYDPATDQWANCSNMEARRSTLGVAVLNGCIYAVGGFDGTTG 509

Human   400 LNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNG--NECLFTAEVYNTESNQWTV 462
            |::||.|:|:|:.|..||.|..:||......::|.:|..||::|  .:||.:.|.||.:::.|..
  Fly   510 LSSAEMYDPKTDIWRFIASMSTRRSSVGVGVVHGLLYAVGGYDGFTRQCLSSVERYNPDTDTWVN 574

Human   463 IAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDD 527
            :|.|.|||||.||......:|||||.||....||.|||....|:||::..|...|.|.|:...|.
  Fly   575 VAEMSSRRSGAGVGVLNNILYAVGGHDGPMVRRSVEAYDCETNSWRSVADMSYCRRNAGVVAHDG 639

Human   528 LLFVVGGFNGFTTTFNVECYDEKTDEWYDAHD-MSIYRSALSCCVVPGLANVEEYAARRDNFPGL 591
            ||:||||.:|.:...:||.|...:|.|..... |:|.||....|::.....:||..|.......|
  Fly   640 LLYVVGGDDGTSNLASVEVYCPDSDSWRILPALMTIGRSYAGVCMIDKPMXMEEQGALARQAASL 704

Human   592 A---LRDEVKYSAST 603
            |   |.||...:..|
  Fly   705 AIALLDDENSQAEGT 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLHL10	NP_689680.2	PHA03098	36..572	CDD:222983	190/541 (35%)
		Kelch 1	292..339		14/46 (30%)
		KELCH repeat	329..372	CDD:276965	12/42 (29%)
		Kelch 2	340..386		15/45 (33%)
		KELCH repeat	376..420	CDD:276965	21/43 (49%)
		Kelch 3	388..433		20/44 (45%)
		KELCH repeat	423..466	CDD:276965	14/44 (32%)
		Kelch 4	434..480		19/47 (40%)
		KELCH repeat	470..513	CDD:276965	20/42 (48%)
		Kelch 5	481..527		19/45 (42%)
		KELCH repeat	517..561	CDD:276965	16/44 (36%)
		Kelch 6	529..574		16/45 (36%)
kel	NP_476589.4	BTB_POZ_KLHL2-like	136..255	CDD:349544	43/124 (35%)
		PHA03098	150..675	CDD:222983	187/535 (35%)
		KELCH repeat	439..482	CDD:276965	12/42 (29%)
		KELCH repeat	486..530	CDD:276965	21/43 (49%)
		KELCH repeat	533..580	CDD:276965	15/46 (33%)
		KELCH repeat	582..626	CDD:276965	20/43 (47%)
		KELCH repeat	629..674	CDD:276965	16/44 (36%)