Protein Alignment CG10555 and SS18

DIOPT Version :9

• Sequence 1: NP_001285016.1
• Gene: CG10555 / 31771
• FlyBaseID: FBgn0030034
• Length: 926
• Species: Drosophila melanogaster
• Sequence 2: NP_001007560.1
• Gene: SS18 / 6760
• HGNCID: 11340
• Length: 418
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 178/547 - (32%)
• Similarity: 204/547 - (37%)
• Gaps: 172/547 - (31%)

  Fly   129 ANMQGGGGGGVPQQVNSAQIQKMLDENCGLIQTIQDFQSMGKAQECMSYHVALHRNLVYLAQLAD 193
            |..|.|.|     ::..|.||||||:|..|||.|.|.|:.||..||..|...||.||||||.:||
Human     7 APRQRGKG-----EITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIAD 66

  Fly   194 PAMNISQILPPPHILQTQAMQQGGQQTPPTGPHGM-LGGPPQQQQQPGQGPVPGQPGQGPPQMGM 257
            ...|:..:||.|   .||.|        |.||.|| ..|||...:.... |..|..|.|||...|
Human    67 SNQNMQSLLPAP---PTQNM--------PMGPGGMNQSGPPPPPRSHNM-PSDGMVGGGPPAPHM 119

  Fly   258 Q-QHGGDPQGPPVQMPPYGAQQQPQPHPGLPPGAQQQSQQQQQQQQQQQQQQQQQQQQQQAAAAA 321
            | |..|...||. .||..|            ||..|.:........
Human   120 QNQMNGQMPGPN-HMPMQG------------PGPNQLNMTNSSMNM------------------- 152

  Fly   322 AAAAAAAAVAAGQQQGPQVSQAGPQQQQQQQHPVYRNAQGQGQPGAGQVPGQGQGPVQSVINPNA 386
              .:::.....|.......||:.|.|.|.        ...||||.....|           .||.
Human   153 --PSSSHGSMGGYNHSVPSSQSMPVQNQM--------TMSQGQPMGNYGP-----------RPNM 196

  Fly   387 APNQQRPNNGPLSGPQNPQQQQQQPQPG-----GQQPP----------NQQQQQQQTGPGGPGPQ 436
            :   .:||.||:...|.|.||...||.|     |||||          |....|:|..|..| ||
Human   197 S---MQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRP-PQ 257

  Fly   437 PGAGGPGVPPPQSPYRVSYQQQQ----QQHSHYPGYPPQPQT-QYQPQGAYPYG---P--PTQGY 491
            .|       |||     .|..|:    .|:||....||:... ||.|.|...||   |  |.|||
Human   258 QG-------PPQ-----QYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGY 310

  Fly   492 GPPPPGPPNAAQGGYHHGPAGAATGASGHGYQPNAGAGQGPPP-GAYPPPPGSQQVPPVPGQQQP 555
            ..|   ..:::| .|:.|      |.|.:|.|.:  |.||||| ..|||            |||.
Human   311 DRP---YEDSSQ-HYYEG------GNSQYGQQQD--AYQGPPPQQGYPP------------QQQQ 351

  Fly   556 PPGPPPPGQPPTGGQQQPPPGPPQSQYGPPPPQNSAGGPPPMGYAGYPPNPG-QYGQAGAGGGPP 619
            .||            ||..||..|. |||     |.|||.|. |..||...| |||
Human   352 YPG------------QQGYPGQQQG-YGP-----SQGGPGPQ-YPNYPQGQGQQYG--------- 388

  Fly   620 PSGYWP--PPPPTSSAQSPYQAYQQQQ 644
              ||.|  |.||....|.|| .|.|.|
Human   389 --GYRPTQPGPPQPPQQRPY-GYDQGQ 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10555	NP_001285016.1	SSXT	141..200	CDD:282835	30/58 (52%)
SS18	NP_001007560.1	Transcriptional activation	2..186		74/237 (31%)
		SSXT	14..73	CDD:282835	31/63 (49%)
		SH2-binding. /evidence=ECO:0000255	50..53		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..118		18/52 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..418		102/307 (33%)
		2 X 13 AA imperfect tandem repeats	344..369		16/54 (30%)
		SH2-binding. /evidence=ECO:0000255	374..377		1/3 (33%)
		SH3-binding. /evidence=ECO:0000255	392..401		4/8 (50%)
		SH2-binding. /evidence=ECO:0000255	413..416		178/547 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10113
eggNOG	1	0.900	-	-		E1_KOG3227
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1442230at2759
OrthoFinder	1	1.000	-	-		FOG0001535
OrthoInspector	1	1.000	-	-		otm40304
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23107
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4299
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.950