DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and HTR3B

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_006019.1 Gene:HTR3B / 9177 HGNCID:5298 Length:441 Species:Homo sapiens


Alignment Length:330 Identity:94/330 - (28%)
Similarity:158/330 - (47%) Gaps:36/330 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 MILVLSFISSSTANPDAKRLY---DDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQI 71
            :::....:::.|.:|....||   ..||..|:|.||||.|.|.|.||.:.|.:..::||:.:|||
Human    13 ILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQI 77

  Fly    72 MTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNY-- 134
            :.|::|.::.|.|..|.|....:..:..:.:|...||.|||::      |..|.:.....|.|  
Human    78 LKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII------NEFVDIERYPDLPYVY 136

  Fly   135 ---TGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGV 196
               :|.:|...|....|:|.::...||||.|.|.:.|.|..:....|||..:     .:..::..
Human   137 VNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFL-----RSPEDIQH 196

  Fly   197 DLSEFYTSVEWDILEVPAVRNEKFYTCCDEP---YLDITFNITMRRKTLFYTVNLIIPCMGISFL 258
            |...|....||::|.|.:.     |:.....   :..|.||:.|||..|.|.|:|:||.:.:..:
Human   197 DKKAFLNDSEWELLSVSST-----YSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLV 256

  Fly   259 TILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTV 323
            .:..||||.:...::....|:|:..|||.:.::..:|.:....||:|.|         |:||:..
Human   257 DLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHF---------FTICMAF 312

  Fly   324 LVLNI 328
            |||::
Human   313 LVLSL 317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 66/228 (29%)
Cys-loop 150..164 CDD:349832 6/13 (46%)
LGIC_TM_nAChR 242..>331 CDD:349866 26/87 (30%)
TM1 helix 242..266 CDD:349866 8/23 (35%)
TM2 helix 274..295 CDD:349866 5/20 (25%)
TM3 helix 306..328 CDD:349866 7/21 (33%)
Neur_chan_memb <683..760 CDD:460753
HTR3BNP_006019.1 LIC 8..435 CDD:455710 94/330 (28%)
LGIC_ECD_5-HT3B 29..238 CDD:349813 65/224 (29%)
Cys-loop 155..169 CDD:349813 6/13 (46%)
HA-stretch, determines single-channel conductance in 5-HT3 receptors. /evidence=ECO:0000269|PubMed:12867984 381..413
Blue background indicates that the domain is not in the aligned region.

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