DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and CHRNA6

DIOPT Version :9

Sequence 1:NP_001285015.1 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_004189.1 Gene:CHRNA6 / 8973 HGNCID:15963 Length:494 Species:Homo sapiens


Alignment Length:744 Identity:238/744 - (31%)
Similarity:323/744 - (43%) Gaps:287/744 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 KRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEP 91
            :||:..|.|:||:.:|||.||:|.:||..::.::||.:|:..||||.||||:...|.||||:|:|
Human    35 ERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDP 99

  Fly    92 KEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEY 156
            .||.|:|.|.||:|.||:|||||||||.|:|:|...|||.|.|.|.:.|.||||:||||.:|:.:
Human   100 MEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITF 164

  Fly   157 FPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFY 221
            ||||.|.|.:||||||||..::||.         ::...||:::|:.:.||:|::....:::..|
Human   165 FPFDHQNCSLKFGSWTYDKAEIDLL---------IIGSKVDMNDFWENSEWEIIDASGYKHDIKY 220

  Fly   222 TCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVF 286
            .||:|.|.|||::..:||..:|||:||||||:.|||||:||||||||.||||:|.||:|||||||
Human   221 NCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVF 285

  Fly   287 FLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLP 351
            .|::.|.||.|||||||:|:::|||||..|.||.|||.|||||:|:|.||||..||:|||:..||
Human   286 LLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLP 350

  Fly   352 RFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQH 416
            :.|:||.||                                                        
Human   351 QVLLMRWPL-------------------------------------------------------- 359

  Fly   417 RVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLD 481
                                                                    .:|.|    
Human   360 --------------------------------------------------------DKTRG---- 364

  Fly   482 HPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAH 546
                         |.|.....|.......|....||:.      |....|.        |.|:: 
Human   365 -------------TGSDAVPRGLARRPAKGKLASHGEP------RHLKECF--------HCHKS- 401

  Fly   547 ASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLHH 611
                                  |.:||                          |...|.||.|  
Human   402 ----------------------NELAT--------------------------SKRRLSHQPL-- 416

  Fly   612 QQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGVC 676
                  |...:..:|                                                  
Human   417 ------QWVVENSEH-------------------------------------------------- 425

  Fly   677 DILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMVL 741
                                       .||:...::.|.:||:..:...|:..|::||||||||:
Human   426 ---------------------------SPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVV 463

  Fly   742 DRLFLWIFTIAVVVGTAGIILQAPTLYDT 770
            ||:|||:|.|..|.||||:.|| |.|.:|
Human   464 DRVFLWVFIIVCVFGTAGLFLQ-PLLGNT 491

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_001285015.1 Neur_chan_LBD 26..241 CDD:280998 102/213 (48%)
Neur_chan_memb 248..>359 CDD:280999 76/110 (69%)
Neur_chan_memb <683..760 CDD:280999 26/76 (34%)
CHRNA6NP_004189.1 Neur_chan_LBD 34..484 CDD:332142 233/734 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 251 1.000 Domainoid score I2107
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20888
Inparanoid 1 1.050 485 1.000 Inparanoid score I1448
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm8639
orthoMCL 1 0.900 - - OOG6_101158
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X294
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.870

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