DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and chrnb3a

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_957514.1	Gene:	chrnb3a / 794401	ZFINID:	ZDB-GENE-040108-1	Length:	467	Species:	Danio rerio

Alignment Length:	746	Identity:	228/746 - (30%)
Similarity:	303/746 - (40%)	Gaps:	327/746 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DDLLSN----YNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEP 91
            |.||.|    |.|.||||::..|.:|||..||:|||:||:.|||:||||:|:.:.|.||||:|.|
Zfish    33 DTLLRNLFRGYQKWVRPVLHANDTITVRFGLKISQLVDVDEKNQLMTTNVWLWEEWTDYKLRWNP 97

  Fly    92 KEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEY 156
            ::|||:..:.|||:.||.||||||.||||.||.:|.|||.:.:.|.:.|.|||.|||:|.:||.:
Zfish    98 EDYGGITSIRVPSETIWLPDIVLYENADGRFEGSLMTKAIVRFNGTIMWTPPASYKSACTMDVTF 162

  Fly   157 FPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFY 221
            ||||.|.|.||||||||||..|||         .:|:..||..:|:.:.||:||.....|..:..
Zfish   163 FPFDRQNCSMKFGSWTYDGTMVDL---------TLVDAYVDRKDFFDNGEWEILNATGQRGSRRD 218

  Fly   222 TCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVF 286
            .....|||  |::..::|..||||:.|||||:|:||||:||||||||.|||:|||.|:|:|||||
Zfish   219 GIYSYPYL--TYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVF 281

  Fly   287 FLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQT-HTMAPWVRTVFINQL 350
            .|::.||||.:|.|:||:|:::||.||..||||.|||.|:|:|.||..| |.|||||:::|:.:|
Zfish   282 LLVIEEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSATYHPMAPWVKSLFLQRL 346

  Fly   351 PRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQ 415
            ||.|.||
Zfish   347 PRLLCMR---------------------------------------------------------- 353

  Fly   416 HRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLL 480
                                    ||.                           ::||
Zfish   354 ------------------------GHT---------------------------DRYQ------- 360

  Fly   481 DHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQA 545
             :|
Zfish   361 -YP-------------------------------------------------------------- 362

  Fly   546 HASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLH 610
                   |:.:.:|                           ::.:||..|
Zfish   363 -------DIELRSP---------------------------ELKRGMKKG--------------- 378

  Fly   611 HQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGV 675
                        ||:                  :|||
Zfish   379 ------------QQK------------------SAGG---------------------------- 385

  Fly   676 CDILPACQREGGPHCCSGRGNVR----QRWHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKY 736
                             ||..|:    |.|...  |.||...|.||:...|||.....|.:|||:
Zfish   386 -----------------GRAGVKEDENQAWIAL--LEKATHSVHYISRHIRKEHFIREVVQDWKF 431

  Fly   737 VAMVLDRLFLWIFTIAVVVGTAGIILQAPTL 767
            ||.||||:|||.|....|:||  |::..|.|
Zfish   432 VAQVLDRIFLWAFLTVSVLGT--ILIFTPAL 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	104/213 (49%)
		Neur_chan_memb	248..>359	CDD:280999	71/111 (64%)
		Neur_chan_memb	<683..760	CDD:280999	31/80 (39%)
chrnb3a	NP_957514.1	LIC	9..459	CDD:273305	226/743 (30%)
		Neur_chan_LBD	32..236	CDD:280998	104/213 (49%)
		Neur_chan_memb	243..456	CDD:280999	118/519 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2065
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820