DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and Htr3a

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_006243083.1	Gene:	Htr3a / 79246	RGDID:	61818	Length:	488	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	128/461 - (27%)
Similarity:	210/461 - (45%)	Gaps:	93/461 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IDMILVLSFIS----------------SSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIK 56
            |..:|:..|:|                .||..|...||.|.||:||.|.||||.:......|.|.
  Rat     5 IPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVSID 69

  Fly    57 LKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGN 121
            :.:..:::|:.|||::||.:|..|.|.|..|:|.|:::..|..|.:|:|.||.|||::      |
  Rat    70 VIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILI------N 128

  Fly   122 FEVTLATKATLNYT-----GRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSW--TYDGFQVD 179
            ..|.:....::.|.     |.|:...|....::|.:|:..||||.|.|.:.|.||  |.....:.
  Rat   129 EFVDVGKSPSIPYVYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINIS 193

  Fly   180 LRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFY 244
            |....|       ||..|.|.|....||::|.| ..:.::|.......|.::.|.:.:||:.|||
  Rat   194 LWRTPE-------EVRSDKSIFINQGEWELLGV-FTKFQEFSIETSNSYAEMKFYVVIRRRPLFY 250

  Fly   245 TVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVL 309
            .|:|::|.:.:..:.|:.|.||.||||:||..|::||..:||.:::::.:|.|::..||:|.:.:
  Rat   251 AVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFV 315

  Fly   310 FTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVM------RRP--------- 359
            ..|.|...|:..|:.::.:..:......:..|:|.:.::::...|.:      .||
  Rat   316 VCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLGEQPMAHRPPATFQANKT 380

  Fly   360 ------LYPI-----------SEMIKSSRRLMVRTCNGLELRDQIPPLPPP-----------VAL 396
                  |.|.           .::.|:||.           ||.  |||||           ..|
  Rat   381 DDCSGSLLPAMGNHCSHVGSPQDLEKTSRS-----------RDS--PLPPPREASLAVRGLLQEL 432

  Fly   397 SRMHHS 402
            |.:.||
  Rat   433 SSIRHS 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	70/221 (32%)
		Neur_chan_memb	248..>359	CDD:280999	29/116 (25%)
		Neur_chan_memb	<683..760	CDD:280999
Htr3a	XP_006243083.1	LIC	5..482	CDD:273305	128/461 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810