DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and lgc-24

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_001123110.2 Gene:lgc-24 / 6418837 WormBaseID:WBGene00045385 Length:389 Species:Caenorhabditis elegans


Alignment Length:397 Identity:86/397 - (21%)
Similarity:149/397 - (37%) Gaps:77/397 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQ 70
            :.|.:.||:|...:..:.....:|..||..|||..:  .|...:.|.....|::..:..::..:.
 Worm     8 LVIHIHLVVSQWETGKSFTVLTKLRSDLFKNYNGSM--PVGKGEYLEATPSLEVGFIHFIDDDHG 70

  Fly    71 IMTTNLWVEQSWYDYKLKWEPKEYGGVEML------HVPSDHIWRPDIVLYNNADGNF-EVTLA- 127
            .|:..:..|.:|.|.:|||.|..|.||..:      ....::.|.| ||.|.:.|..: |:.|. 
 Worm    71 FMSVVINAELTWIDERLKWNPANYSGVREIVEKTFEFRKDNNCWMP-IVKYRSYDRRYSELDLLE 134

  Fly   128 ---TKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTC-VMKFGSWTYDGFQVDLRHIDELNG 188
               .:..::|.|.::.....:..:.|:.....:|.|.|.| :|...:...|.|    |.:.. ||
 Worm   135 FSDARTLISYKGEIKTALQTMVTTKCQFSFGEYPNDYQNCSIMLIPNQNADEF----RFVSP-NG 194

  Fly   189 TNVVEVGVDLSEFYTSVEWDILEVPAVR----------NEKFYTCCDEPY-------------LD 230
                         |.:.:::.||..|||          :..|||..:..:             .:
 Worm   195 -------------YCNPKFENLEHRAVRVHDLHLMGVESNIFYTFANTYFTAEEVTGFEYMAKTE 246

  Fly   231 ITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFF------LL 289
            ..||:..:|......|.|.||.:.||...|:....|:        ..||......||      |.
 Worm   247 FRFNLMFKRVNKLLNVKLSIPSILISMFLIIAGLFPN--------GYSIFGYAYCFFVEVMHGLY 303

  Fly   290 LAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFL 354
            :::|:|.....:|..|...|..:|...|..|..  |.:::.|:.:.....|   .||.:.  |..
 Worm   304 VSKILPNDIRGIPYHGALALCFLIETVFLFCWK--VFSVYARNQKLFAQLP---NVFADN--RVF 361

  Fly   355 VMRRPLY 361
            |::...|
 Worm   362 VLKFVFY 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 53/252 (21%)
Cys-loop 150..164 CDD:349832 4/13 (31%)
LGIC_TM_nAChR 242..>331 CDD:349866 22/94 (23%)
TM1 helix 242..266 CDD:349866 7/23 (30%)
TM2 helix 274..295 CDD:349866 6/26 (23%)
TM3 helix 306..328 CDD:349866 5/21 (24%)
Neur_chan_memb <683..760 CDD:460753
lgc-24NP_001123110.2 LGIC_ECD 62..226 CDD:475126 40/182 (22%)
Blue background indicates that the domain is not in the aligned region.

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