DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and Htr3b

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_071525.1 Gene:Htr3b / 58963 RGDID:61820 Length:437 Species:Rattus norvegicus


Alignment Length:326 Identity:87/326 - (26%)
Similarity:158/326 - (48%) Gaps:17/326 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 WFQVTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNL 67
            |..:.:.::.:|...:....|....||...||..|:|.||||.|..:|.||.:.|.:..::||::
  Rat     5 WSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDV 69

  Fly    68 KNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATL 132
            :||.:.|::|..:.|.|..|.|....:..::.:.:|...||.|||::....|......| ....:
  Rat    70 QNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFVDVERSPDL-PYVYV 133

  Fly   133 NYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVD 197
            |.:|.:....|....|:|.:....||||.|.|.:.|.|..:....:||..:     .|..::..|
  Rat   134 NSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFL-----RNQEDIEND 193

  Fly   198 LSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILV 262
            ...|....||.:|.|.:..:.:..:..|  :..|.||:.:||..|.|.|:|:||.:.:..:.:..
  Rat   194 KRSFLNDSEWQLLSVTSTYHIRQSSAGD--FAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGS 256

  Fly   263 FYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLN 327
            ||||.:...::....::|:..|||.:.:::.:|.::....|:|.|         |::|:.:|||:
  Rat   257 FYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGVF---------FTVCMALLVLS 312

  Fly   328 I 328
            :
  Rat   313 L 313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 61/217 (28%)
Cys-loop 150..164 CDD:349832 6/13 (46%)
LGIC_TM_nAChR 242..>331 CDD:349866 23/87 (26%)
TM1 helix 242..266 CDD:349866 8/23 (35%)
TM2 helix 274..295 CDD:349866 4/20 (20%)
TM3 helix 306..328 CDD:349866 6/21 (29%)
Neur_chan_memb <683..760 CDD:460753
Htr3bNP_071525.1 LGIC_ECD 25..233 CDD:475126 60/215 (28%)
LGIC_TM_5-HT3 236..432 CDD:349865 23/87 (26%)
TM1 helix 236..260 CDD:349865 8/23 (35%)
TM2 helix 268..289 CDD:349865 4/20 (20%)
TM3 helix 300..322 CDD:349865 6/23 (26%)
HA-stretch, determines single-channel conductance in 5-HT3 receptors. /evidence=ECO:0000250|UniProtKB:O95264 377..409
TM4 helix 407..429 CDD:349865
Blue background indicates that the domain is not in the aligned region.

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