DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and Htr3b

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_071525.1	Gene:	Htr3b / 58963	RGDID:	61820	Length:	437	Species:	Rattus norvegicus

Alignment Length:	326	Identity:	87/326 - (26%)
Similarity:	158/326 - (48%)	Gaps:	17/326 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WFQVTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNL 67
            |..:.:.::.:|...:....|....||...||..|:|.||||.|..:|.||.:.|.:..::||::
  Rat     5 WSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDV 69

  Fly    68 KNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATL 132
            :||.:.|::|..:.|.|..|.|....:..::.:.:|...||.|||::....|......| ....:
  Rat    70 QNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFVDVERSPDL-PYVYV 133

  Fly   133 NYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVD 197
            |.:|.:....|....|:|.:....||||.|.|.:.|.|..:....:||..:     .|..::..|
  Rat   134 NSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFL-----RNQEDIEND 193

  Fly   198 LSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILV 262
            ...|....||.:|.|.:..:.:..:..|  :..|.||:.:||..|.|.|:|:||.:.:..:.:..
  Rat   194 KRSFLNDSEWQLLSVTSTYHIRQSSAGD--FAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGS 256

  Fly   263 FYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLN 327
            ||||.:...::....::|:..|||.:.:::.:|.::....|:|.|         |::|:.:|||:
  Rat   257 FYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGVF---------FTVCMALLVLS 312

  Fly   328 I 328
            :
  Rat   313 L 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	61/214 (29%)
		Neur_chan_memb	248..>359	CDD:280999	20/81 (25%)
		Neur_chan_memb	<683..760	CDD:280999
Htr3b	NP_071525.1	LIC	30..431	CDD:273305	84/301 (28%)
		Neur_chan_LBD	30..233	CDD:280998	59/210 (28%)
		Neur_chan_memb	242..>313	CDD:280999	20/79 (25%)
		HA-stretch	377..409
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900