DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha3 and htr3a

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:XP_073791438.1 Gene:htr3a / 571641 ZFINID:ZDB-GENE-071012-5 Length:494 Species:Danio rerio


Alignment Length:464 Identity:129/464 - (27%)
Similarity:218/464 - (46%) Gaps:71/464 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYK 86
            ||....||.:.|.:.|.|.||||.:...:.||.|.|.:..:::|:.|||::||.:|..|.|.|..
Zfish    34 ANATLVRLNEFLSAGYKKGVRPVRDWRQSTTVAIDLMVYAILNVDEKNQVLTTYVWYRQQWTDEF 98

  Fly    87 LKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYT-----GRVEWRPPAIY 146
            |.|:|:|:..|:.:.:|:.:||.|||::      |..|.:.....:.|.     |.|....|...
Zfish    99 LMWDPEEFDEVKKISIPTANIWIPDILI------NEFVDVGKSPDIPYVYVGHDGLVSNYKPIQV 157

  Fly   147 KSSCEIDVEYFPFDEQTCVMKFGSW--TYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDI 209
            .::|.:::..||:|.|.|.:.|.||  |.....:.|....|       .|..|.|.|....||::
Zfish   158 VTACSLNIYNFPYDVQKCSLTFQSWLHTTKDINITLMRSPE-------AVKTDKSVFMNQGEWEL 215

  Fly   210 LEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVS 274
            |.|.:..| .|....|:.|.::.|::.:||:.|||||||::|.|.:..:.|:.||||.||||:||
Zfish   216 LHVLSTYN-AFSIDNDDYYAEMKFHVVIRRRPLFYTVNLLLPSMFLMVMDIVGFYLPPDSGERVS 279

  Fly   275 LSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMA 339
            ..|::||..:||.:::::.:|.|::..||:|.:.:..|.|...|:..:||::.:..:......:.
Zfish   280 FKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLTESVLIVRLVHKQDLQSRVP 344

  Fly   340 PWVRTVFINQLPRFLVMRR-------------PLYPISEMIKSSRRLMVRTCNGLELRDQIPPLP 391
            .||:.:.:.:....|.:|.             |||..:.|            |..|.:|.:..:.
Zfish   345 QWVKHLVLEKATVLLCIRNKKICSFRSQGSDLPLYKENNM------------NTAEQQDTLTMIT 397

  Fly   392 PPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQ 456
            .  |:...|||.:.:..|                  |..:|.|   ::.|.|.  ||.|....::
Zfish   398 S--AIHCNHHSCEGSRDS------------------GRTLGLG---LSAHESG--PPVMDGILRE 437

  Fly   457 TSTTSSLID 465
            .:|....::
Zfish   438 ITTIRQFLE 446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 67/224 (30%)
Cys-loop 150..164 CDD:349832 5/13 (38%)
LGIC_TM_nAChR 242..>331 CDD:349866 35/88 (40%)
TM1 helix 242..266 CDD:349866 12/23 (52%)
TM2 helix 274..295 CDD:349866 6/20 (30%)
TM3 helix 306..328 CDD:349866 5/21 (24%)
Neur_chan_memb <683..760 CDD:460753
htr3aXP_073791438.1 None
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.