DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and Htr3b

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_064670.1	Gene:	Htr3b / 57014	MGIID:	1861899	Length:	437	Species:	Mus musculus

Alignment Length:	424	Identity:	102/424 - (24%)
Similarity:	189/424 - (44%)	Gaps:	53/424 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WFQVTIDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNL 67
            |..:.:.::.:|...:....|....||...||..|:|.||||.|..:|.||.:.|.:..::||::
Mouse     5 WSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDV 69

  Fly    68 KNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATL 132
            :||.:.|::|..:.|.|..|.|....:..::.:.:|...:|.|||::....|......| ....:
Mouse    70 QNQKLKTSVWYREVWNDEFLSWNSSLFDEIQEISLPLSALWAPDIIINEFVDVERSPDL-PYVYV 133

  Fly   133 NYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVD 197
            |.:|.:....|....|:|.:....||||.|.|.:.|.|..:....:||..:     .|..::..|
Mouse   134 NSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFL-----RNREDIEND 193

  Fly   198 LSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILV 262
            ...|....||.:|.|.:..:.:..:..|  :..|.||:.:||..|.|.|:|:||.:.:..:.:..
Mouse   194 KRAFMNDSEWQLLSVSSTYHIRQSSAGD--FAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGS 256

  Fly   263 FYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLN 327
            ||||.:...::....::|:..|||.:.:::.:|.::...||:|.|         |::|:.:|||:
Mouse   257 FYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTPLIGVF---------FTVCMALLVLS 312

  Fly   328 IHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPP 392
                                  |.:.:::.:.||   |...|.:...:....|....::
Mouse   313 ----------------------LSKSILLIKFLY---EERHSGQERPLMCLQGDSDAEE------ 346

  Fly   393 PVALSRMH-HSPKTTSRSTSPHLQHRVQTYNLMD 425
                ||:: .:|:.....:..|.:|||.:..|.|
Mouse   347 ----SRLYLGAPRADVTESPVHQEHRVPSDTLKD 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	60/214 (28%)
		Neur_chan_memb	248..>359	CDD:280999	22/110 (20%)
		Neur_chan_memb	<683..760	CDD:280999
Htr3b	NP_064670.1	LIC	30..431	CDD:273305	99/399 (25%)
		Neur_chan_LBD	30..233	CDD:280998	58/210 (28%)
		Neur_chan_memb	242..>313	CDD:280999	21/101 (21%)
		HA-stretch	377..409		102/424 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900