Protein Alignment nAChRalpha3 and LOC5668163

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: XP_001689187.2
• Gene: LOC5668163 / 5668163
• VectorBaseID: AGAMI1_011448
• Length: 442
• Species: Anopheles gambiae
• Alignment Length: 290
• Identity: 62/290 - (21%)
• Similarity: 114/290 - (39%)
• Gaps: 37/290 - (12%)

  Fly    35 SNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEM 99
            ::||...|||....|.|.:.|..::..:..|...:..:...|.:...|||..|.|..:..|.:|.
Mosquito    50 TSYNPRYRPVKYQQDRLAMYIGAEVINVEKVRNYDSRLEITLELLMQWYDAFLHWNKRTSGNIET 114

  Fly   100 LHVPSDHIWRPDIVLYNNADG----NFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFD 160
            ::|....:|.|.....:....    |.:.....|..|:|.|.|.:.....:...|..:..|:.||
Mosquito   115 INVAEQDLWTPTFAAKSFQRSPRIQNTKQCTRVKCHLSYDGEVIYTVLCTFTVDCYTEARYWAFD 179

  Fly   161 EQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLS-EFYTSVEWDI--LEVPAVRNEKFYT 222
            .:.|.::..|..||..|:.|.|...           .|| ..|:.:.:.|  .::..|.:    |
Mosquito   180 TKICTLRIYSVEYDTNQLSLFHFQR-----------RLSYPSYSLLPYKITSFQMATVNS----T 229

  Fly   223 CCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTV-- 285
            ...|..:||.....:....:.:.|.:::.|    ||.:...:...|:..:   :|:::|...:
Mosquito   230 MSPEFRMDIVIERLVGSHLVVFLVLIVMFC----FLNLFSLWFSIDTSAR---TIAVVLGTVMQG 287

  Fly   286 FFLL------LAEIIPPTSLVVPLLGKFVL 309
            .||:      :.::.|..:|...|||.|.|
Mosquito   288 MFLVILYWYGMVKMKPVITLAHLLLGSFAL 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	46/214 (21%)
		Cys-loop	150..164	CDD:349832	4/13 (31%)
		LGIC_TM_nAChR	242..>331	CDD:349866	16/76 (21%)
		TM1 helix	242..266	CDD:349866	4/23 (17%)
		TM2 helix	274..295	CDD:349866	4/28 (14%)
		TM3 helix	306..328	CDD:349866	2/4 (50%)
		Neur_chan_memb	<683..760	CDD:460753
LOC5668163	XP_001689187.2	None